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Marthandan, S., Freeburn, R., Steinbrecht, S., Pawelec, G. and Barnett, Y., 2014. SENIEUR status of the originating cell donor negates certain ‘anti-immunosenescence’ effects of ebselen and N-acetyl cysteine in human T cell clone cultures. Immunology and Ageing, 11. ISSN 1742-4933
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Abstract
Background: Damage to T cells of the immune system by reactive oxygen species may result in altered cell function or cell death and thereby potentially impact upon the efficacy of a subsequent immune response. Here, we assess the impact of the antioxidants Ebselen and N-acetyl cysteine on a range of biological markers in human T cells derived from a SENIEUR status donor. In addition, the impact of these antioxidants on different MAP kinase pathways in T cells from donors of different ages was also examined. Methods: T cell clones were derived from healthy 26, 45 and SENIEUR status 80 year old people and the impact of titrated concentrations of Ebselen or N-acetyl cysteine on their proliferation and in vitro lifespan, GSH:GSSG ratio as well as levels of oxidative DNA damage and on MAP kinase signaling pathways was examined.
| Item Type: | Journal article | ||||
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| Publication Title: | Immunology and Ageing | ||||
| Creators: | Marthandan, S., Freeburn, R., Steinbrecht, S., Pawelec, G. and Barnett, Y. | ||||
| Publisher: | BioMed Central | ||||
| Date: | 2014 | ||||
| Volume: | 11 | ||||
| ISSN: | 1742-4933 | ||||
| Identifiers: |
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| Divisions: | Schools > School of Science and Technology | ||||
| Record created by: | EPrints Services | ||||
| Date Added: | 09 Oct 2015 09:58 | ||||
| Last Modified: | 07 Jun 2019 09:34 | ||||
| URI: | https://irep.ntu.ac.uk/id/eprint/5782 |
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