SENIEUR status of the originating cell donor negates certain ‘anti-immunosenescence’ effects of ebselen and N-acetyl cysteine in human T cell clone cultures

Marthandan, S, Freeburn, R, Steinbrecht, S, Pawelec, G and Barnett, Y, 2014. SENIEUR status of the originating cell donor negates certain ‘anti-immunosenescence’ effects of ebselen and N-acetyl cysteine in human T cell clone cultures. Immunology and Ageing, 11. ISSN 1742-4933

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Abstract

Background: Damage to T cells of the immune system by reactive oxygen species may result in altered cell function or cell death and thereby potentially impact upon the efficacy of a subsequent immune response. Here, we assess the impact of the antioxidants Ebselen and N-acetyl cysteine on a range of biological markers in human T cells derived from a SENIEUR status donor. In addition, the impact of these antioxidants on different MAP kinase pathways in T cells from donors of different ages was also examined. Methods: T cell clones were derived from healthy 26, 45 and SENIEUR status 80 year old people and the impact of titrated concentrations of Ebselen or N-acetyl cysteine on their proliferation and in vitro lifespan, GSH:GSSG ratio as well as levels of oxidative DNA damage and on MAP kinase signaling pathways was examined.

Item Type:	Journal article
Publication Title:	Immunology and Ageing
Creators:	Marthandan, S., Freeburn, R., Steinbrecht, S., Pawelec, G. and Barnett, Y.
Publisher:	BioMed Central
Date:	2014
Volume:	11
ISSN:	1742-4933
Identifiers:	Number Type 10.1186/s12979-014-0017-5 DOI
Divisions:	Schools > School of Science and Technology
Record created by:	EPrints Services
Date Added:	09 Oct 2015 09:58
Last Modified:	07 Jun 2019 09:34
URI:	https://irep.ntu.ac.uk/id/eprint/5782

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