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Imrie, H. 
ORCID: 0000-0001-5214-3706, Fowkes, F.J.I., Migot-Nabias, F., Michon, P., Justice, A., Deloron, P., Luty, J.F. and Day, K.P.,
2006.
Association of haptoglobin levels with age, parasite density and haptoglobin genotype in a malaria-endemic area of Gabon.
American Journal of Tropical Medicine and Hygiene, 74 (1), pp. 26-30.
ISSN 0002-9637
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Abstract
Haptoglobin (Hp) levels were investigated in relation to host genotype in a malaria-endemic area in Gabon. A cross-sectional study of 1–12-year-old children was conducted in the rainy season, a period of high malaria transmission, to examine this relationship. Variables that influenced Hp levels were Hp genotype, location, and age interacting with parasite density. At low parasite densities, there was a negative correlation between Hp levels and age. At higher densities, there was a positive correlation with age. This suggests that in the presence of greater parasite-induced hemolysis, older children are capable of increased production of Hp. Sickle cell trait and ABO blood group was not associated with Hp levels in this population.
| Item Type: | Journal article |
|---|---|
| Publication Title: | American Journal of Tropical Medicine and Hygiene |
| Creators: | Imrie, H., Fowkes, F.J.I., Migot-Nabias, F., Michon, P., Justice, A., Deloron, P., Luty, J.F. and Day, K.P. |
| Publisher: | The American Society of Tropical Medicine and Hygiene |
| Date: | 2006 |
| Volume: | 74 |
| Number: | 1 |
| ISSN: | 0002-9637 |
| Rights: | Copyright © 2006 by The American Society of Tropical Medicine and Hygiene |
| Divisions: | Schools > School of Animal, Rural and Environmental Sciences |
| Record created by: | EPrints Services |
| Date Added: | 09 Oct 2015 09:59 |
| Last Modified: | 09 Jun 2017 13:16 |
| URI: | https://irep.ntu.ac.uk/id/eprint/6022 |
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