Association of haptoglobin levels with age, parasite density and haptoglobin genotype in a malaria-endemic area of Gabon

Imrie, H ORCID: https://orcid.org/0000-0001-5214-3706, Fowkes, FJI, Migot-Nabias, F, Michon, P, Justice, A, Deloron, P, Luty, JF and Day, KP, 2006. Association of haptoglobin levels with age, parasite density and haptoglobin genotype in a malaria-endemic area of Gabon. American Journal of Tropical Medicine and Hygiene, 74 (1), pp. 26-30. ISSN 0002-9637

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Abstract

Haptoglobin (Hp) levels were investigated in relation to host genotype in a malaria-endemic area in Gabon. A cross-sectional study of 1–12-year-old children was conducted in the rainy season, a period of high malaria transmission, to examine this relationship. Variables that influenced Hp levels were Hp genotype, location, and age interacting with parasite density. At low parasite densities, there was a negative correlation between Hp levels and age. At higher densities, there was a positive correlation with age. This suggests that in the presence of greater parasite-induced hemolysis, older children are capable of increased production of Hp. Sickle cell trait and ABO blood group was not associated with Hp levels in this population.

Item Type:	Journal article
Publication Title:	American Journal of Tropical Medicine and Hygiene
Creators:	Imrie, H., Fowkes, F.J.I., Migot-Nabias, F., Michon, P., Justice, A., Deloron, P., Luty, J.F. and Day, K.P.
Publisher:	The American Society of Tropical Medicine and Hygiene
Date:	2006
Volume:	74
Number:	1
ISSN:	0002-9637
Rights:	Copyright © 2006 by The American Society of Tropical Medicine and Hygiene
Divisions:	Schools > School of Animal, Rural and Environmental Sciences
Record created by:	EPrints Services
Date Added:	09 Oct 2015 09:59
Last Modified:	09 Jun 2017 13:16
URI:	https://irep.ntu.ac.uk/id/eprint/6022

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