STI-GMaS: an open-source environment for simulation of sexually-transmitted infections

Nelson, MR, Sutton, KJ, Brook, BS, Mallet, DG, Simpson, DP and Rank, RG, 2014. STI-GMaS: an open-source environment for simulation of sexually-transmitted infections. BMC Systems Biology, 8, p. 66. ISSN 1752-0509

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Abstract

Background: Sexually-transmitted pathogens often have severe reproductive health implications if treatment is delayed or absent, especially in females. The complex processes of disease progression, namely replication and ascension of the infection through the genital tract, span both extracellular and intracellular physiological scales, and in females can vary over the distinct phases of the menstrual cycle. The complexity of these processes, coupled with the common impossibility of obtaining comprehensive and sequential clinical data from individual human patients, makes mathematical and computational modelling valuable tools in developing our understanding of the infection, with a view to identifying new interventions. While many within-host models of sexually-transmitted infections (STIs) are available in existing literature, these models are difficult to deploy in clinical/experimental settings since simulations often require complex computational approaches.

Item Type:	Journal article
Publication Title:	BMC Systems Biology
Creators:	Nelson, M.R., Sutton, K.J., Brook, B.S., Mallet, D.G., Simpson, D.P. and Rank, R.G.
Publisher:	BioMed Central (BMC)
Date:	2014
Volume:	8
ISSN:	1752-0509
Identifiers:	Number Type 10.1186/1752-0509-8-66 DOI
Rights:	© 2014 Nelson et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Divisions:	Schools > School of Science and Technology
Record created by:	EPrints Services
Date Added:	09 Oct 2015 10:20
Last Modified:	23 Aug 2016 09:09
URI:	https://irep.ntu.ac.uk/id/eprint/11359

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