Low prevalence of an acute phase response in asymptomatic children from a malaria-endemic area of Papua New Guinea

Imrie, H ORCID: https://orcid.org/0000-0001-5214-3706, Fowkes, FJI, Michon, P, Tavul, L, Reeder, JC, Luty, AJF and Day, KP, 2007. Low prevalence of an acute phase response in asymptomatic children from a malaria-endemic area of Papua New Guinea. American Journal of Tropical Medicine and Hygiene, 76 (2), pp. 280-284. ISSN 0002-9637

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Abstract

Levels of C-reactive protein (CRP), a classic marker for the acute phase response (APR), were measured in children with asymptomatic malaria infection in the Amele region of Papua New Guinea (PNG). Despite the presence of parasitemia, the prevalence of CRP levels consistent with an APR (CRP > 10 (xg/mL) was very low (< 10%). Splenomegaly was significantly associated with increased parasitemia (P < 0.001) and CRP levels (P < 0.001), highlighting the importance of splenomegaly as an indicator of recent high density infection in this population. Multivariate analysis showed that CRP levels were significantly associated with splenomegaly, fever, hemoglobin, and age (P < 0.002). CRP levels also increased with increasing parasitemia (P < 0.001) but remained < 3.5 (xg/mL. The low levels of CRP indicate that children in the Amele modulate inflammation associated with malaria.

Item Type:	Journal article
Publication Title:	American Journal of Tropical Medicine and Hygiene
Creators:	Imrie, H., Fowkes, F.J.I., Michon, P., Tavul, L., Reeder, J.C., Luty, A.J.F. and Day, K.P.
Publisher:	The American Society of Tropical Medicine and Hygiene
Date:	2007
Volume:	76
Number:	2
ISSN:	0002-9637
Rights:	Copyright © 2007 by The American Society of Tropical Medicine and Hygiene
Divisions:	Schools > School of Animal, Rural and Environmental Sciences
Record created by:	EPrints Services
Date Added:	09 Oct 2015 09:43
Last Modified:	09 Jun 2017 13:09
URI:	https://irep.ntu.ac.uk/id/eprint/1669

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