Molecular and functional analysis of the tumour antigen T21

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Alshehri, BM, 2015. Molecular and functional analysis of the tumour antigen T21. PhD, Nottingham Trent University.

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Abstract

Immunotherapy is a valuable approach to target tumour cells by stimulating the body’s adaptive immune system. To achieve this objective, it is important to identify and study antigens that are distinctively expressed in cancer and can be used effectively to initiate or enhance immune responses. T21 (Testis clone 21) was identified as a member of cancer/testis antigen (CTAs) family of proteins using a modified SEREX technique and can be considered a promising prostate-associated tumour antigen, shown to elicit a humoral immune response in prostate cancer patients. T21 has also been shown to be over-expressed in malignant glands of the prostate compared to benign glands and stroma at the mRNA level. Since T21 shares significant similarity with the Centrosomal Protein, CEP290, which has been implicated in several cilia associated syndromic disorders such as Joubert syndrome, it was necessary to determine similarities and differences in the expression and functionality of these two molecules to facilitate further studies on the role of T21 in prostate cancer tumourigenesis. As with the majority of identified cancer/testis antigens, the role of T21 in cancer remains undetermined. Therefore, investigations were initiated to understand the potential function of T21 in cancer cells.

Item Type:	Thesis
Creators:	Alshehri, B.M.
Date:	2015
Rights:	This work is the intellectual property of the author, and may also be owned by the research sponsor(s) and/or Nottingham Trent University. You may copy up to 5% of this work for private study, or personal, non-commercial research. Any re-use of the information contained within this document should be fully referenced, quoting the author, title, university, degree level and pagination. Queries or requests for any other use, or if a more substantial copy is required, should be directed in the first instance to the author.
Divisions:	Schools > School of Science and Technology
Record created by:	EPrints Services
Date Added:	09 Oct 2015 09:34
Last Modified:	05 Dec 2017 09:38
URI:	https://irep.ntu.ac.uk/id/eprint/198