Croxall, G, Weston, V, Joseph, S, Manning, G, Cheetham, P and McNally, A ORCID: https://orcid.org/0000-0002-3099-630X, 2011. Increased human pathogenic potential of Escherichia coli from polymicrobial urinary tract infections in comparison to isolates from monomicrobial culture samples. Journal of Medical Microbiology, 60 (1), pp. 102-109. ISSN 0022-2615
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Abstract
The current diagnostic standard procedure outlined by the Health Protection Agency for urinary tract infections (UTIs) in clinical laboratories does not report bacteria isolated from samples containing three or more different bacterial species. As a result many UTIs go unreported and untreated, particularly in elderly patients, where polymicrobial UTI samples are especially prevalent. This study reports the presence of the major uropathogenic species in mixed culture urine samples from elderly patients, and of resistance to front-line antibiotics, with potentially increased levels of resistance to ciprofloxacin and trimethoprim. Most importantly, the study highlights that Escherichia coli present in polymicrobial UTI samples are statistically more invasive (P<0.001) in in vitro epithelial cell infection assays than those isolated from monomicrobial culture samples. In summary, the results of this study suggest that the current diagnostic standard procedure for polymicrobial UTI samples needs to be reassessed, and that E. coli present in polymicrobial UTI samples may pose an increased risk to human health.
Item Type: | Journal article |
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Publication Title: | Journal of Medical Microbiology |
Creators: | Croxall, G., Weston, V., Joseph, S., Manning, G., Cheetham, P. and McNally, A. |
Publisher: | Society for General Microbiology |
Date: | 2011 |
Volume: | 60 |
Number: | 1 |
ISSN: | 0022-2615 |
Identifiers: | Number Type 10.1099/jmm.0.020602-0 DOI |
Rights: | This is an author manuscript that has been accepted for publication in Journal of Medical Microbiology, copyright Society for General Microbiology, but has not been copy-edited, formatted or proofed. Cite this article as appearing in Journal of Medical Microbiology. This version of the manuscript may not be duplicated or reproduced, other than for personal use or within the rule of 'Fair Use of Copyrighted Materials' (section 17, Title 17, US Code), without permission from the copyright owner, Society for General Microbiology. The Society for General Microbiology disclaims any responsibility or liability for errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final copy-edited, published article, which is the version of record, can be found at http://jmm.sgmjournals.org, and is freely available without a subscription 12 months after publication. |
Divisions: | Schools > School of Science and Technology |
Record created by: | EPrints Services |
Date Added: | 09 Oct 2015 11:07 |
Last Modified: | 09 Jun 2017 13:49 |
URI: | https://irep.ntu.ac.uk/id/eprint/22970 |
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