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Ali, SA, Ahmad, M 
ORCID: https://orcid.org/0000-0002-6074-2001, Lynam, J, Mclean, CS, Entwisle, C, Loudon, P, Choolun, E, McArdle, SE ORCID: https://orcid.org/0000-0001-6929-9782, Li, G, Mian, S and Rees, RC ORCID: https://orcid.org/0000-0002-4574-4746,
2004.
Anti-tumour therapeutic efficacy of OX40L in murine tumour model.
Vaccine, 22 (2728), pp. 3585-3594.
ISSN 0264-410X
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Abstract
OX40 ligand (OX40L), a member of TNF superfamily, is a co-stimulatory molecule involved in T cell activation. Systemic administration of mOX40L fusion protein significantly inhibited the growth of experimental lung metastasis and subcutaneous (s.c.) established colon (CT26) and breast (4T1) carcinomas. Vaccination with OX40L was significantly enhanced by combination treatment with intra-tumour injection of a disabled infectious single cycle-herpes simplex virus (DISC-HSV) vector encoding murine granulocyte macrophage-colony stimulating factor (mGM-CSF). Tumour rejection in response to OX40L therapy required functional CD4+ and CD8+ T cells and correlated with splenocyte cytotoxic T lymphocytes (CTLs) activity against the AH-1 gp70 peptide of the tumour associated antigen expressed by CT26 cells. These results demonstrate the potential role of the OX40L in cancer immunotherapy.
| Item Type: | Journal article |
|---|---|
| Publication Title: | Vaccine |
| Creators: | Ali, S.A., Ahmad, M., Lynam, J., Mclean, C.S., Entwisle, C., Loudon, P., Choolun, E., McArdle, S.E., Li, G., Mian, S. and Rees, R.C. |
| Publisher: | Elsevier (not including Cell Press) |
| Place of Publication: | Oxford |
| Date: | 2004 |
| Volume: | 22 |
| Number: | 2728 |
| ISSN: | 0264-410X |
| Identifiers: | Number Type 10.1016/j.vaccine.2004.03.041 DOI |
| Divisions: | Schools > School of Science and Technology |
| Record created by: | EPrints Services |
| Date Added: | 09 Oct 2015 11:10 |
| Last Modified: | 24 Nov 2021 14:27 |
| URI: | https://irep.ntu.ac.uk/id/eprint/23695 |
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