Systems biology in inflammatory bowel diseases

Polytarchou, C ORCID: https://orcid.org/0000-0002-1948-7934, Koukos, G and Iliopoulos, D, 2014. Systems biology in inflammatory bowel diseases. Current Opinion in Gastroenterology, 30 (4), pp. 339-346. ISSN 0267-1379

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Abstract

Purpose of review: Ulcerative colitis (UC) and Crohn’s Disease (CD) are the two predominant types of inflammatory bowel disease (IBD), affecting over 1.4 million individuals in the US. IBD results from complex interactions between pathogenic components, including genetic and epigenetic factors, the immune response and the microbiome through an unknown sequence of events. The purpose of this review is to describe a system biology approach to IBD as a novel and exciting methodology aiming at developing novel IBD therapeutics based on the integration of molecular and cellular "omics" data. Recent Findings: Recent evidence suggested the presence of genetic, epigenetic, transcriptomic, proteomic and metabolomic alterations in IBD patients. Furthermore, several studies have shown that different cell types, including fibroblasts, epithelial, immune and endothelial cells together with the intestinal microbiota are involved in IBD pathogenesis. Novel computational methodologies have been developed aiming to integrate high - throughput molecular data. Summary: A systems biology approach could potentially identify the central regulators (hubs) in the IBD interactome and improve our understanding of the molecular mechanisms involved in IBD pathogenesis. The future IBD therapeutics should be developed on the basis of targeting the central hubs in the IBD network.

Item Type:	Journal article
Publication Title:	Current Opinion in Gastroenterology
Creators:	Polytarchou, C., Koukos, G. and Iliopoulos, D.
Publisher:	Lippincott Williams & Wilkins
Date:	2014
Volume:	30
Number:	4
ISSN:	0267-1379
Identifiers:	Number Type 10.1097/MOG.0000000000000081 DOI
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	03 Feb 2016 10:44
Last Modified:	09 Jun 2017 13:58
URI:	https://irep.ntu.ac.uk/id/eprint/26872

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