Radiotherapy after mastectomy for screen-detected ductal carcinoma in situ

Clements, K, Dodwell, D, Lawrence, G, Ball, G ORCID: https://orcid.org/0000-0001-5828-7129, Francis, A, Pinder, S, Sawyer, E, Wallis, M and Thompson, AM, 2015. Radiotherapy after mastectomy for screen-detected ductal carcinoma in situ. European Journal of Surgical Oncology (EJSO), 41 (10), pp. 1406-1410. ISSN 07487983

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Abstract

Background. A role for radiotherapy after mastectomy for ductal carcinoma in situ (DCIS) is unclear. Using a prospective audit of DCIS detected through the NHS Breast Screening Programme we sought to determine a rationale for the use of postmastectomy radiotherapy for DCIS. Methods. Over a nine year period, from 9,972 patients with screen-detected DCIS and complete surgical, pathology, radiotherapy and follow up data, 2,944 women underwent mastectomy for DCIS of whom 33 (1.12%) received radiotherapy. Results. Use of post mastectomy radiotherapy was significantly associated with a close (<1mm) pathology margin, particularly (χ2(1) 95.81; p<0.00001), DCIS size (χ2 (3) 16.96; p<0.001) and the presence of microinvasion (χ2(1) 3.92; p<0.05). At median follow up 61 months, no woman who received radiotherapy had an ipsilateral further event, and only 1/33 women (3.0%) had a contralateral event. Of the women known not to have had radiotherapy post mastectomy, 45/2,894 (1.6%) had an ipsilateral further event and 83 (2.9%) had a contralateral event. Conclusion: For DCIS treated by mastectomy, a close (<1mm) margin, large tumour size and microinvasion, may merit radiotherapy to reduce ipsilateral recurrence.

Item Type:	Journal article
Publication Title:	European Journal of Surgical Oncology (EJSO)
Creators:	Clements, K., Dodwell, D., Lawrence, G., Ball, G., Francis, A., Pinder, S., Sawyer, E., Wallis, M. and Thompson, A.M.
Publisher:	Elsevier
Date:	2015
Volume:	41
Number:	10
ISSN:	07487983
Identifiers:	Number Type 10.1016/j.ejso.2015.07.021 DOI
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	09 Feb 2016 16:41
Last Modified:	09 Jun 2017 13:59
URI:	https://irep.ntu.ac.uk/id/eprint/26921

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