A Meta-Analysis of Studies of Treatments for Feline Urine Spraying

Mills, DS, Redgate, SE ORCID: https://orcid.org/0000-0002-3122-0343 and Landsberg, GM, 2011. A Meta-Analysis of Studies of Treatments for Feline Urine Spraying. PLoS ONE, 6 (4), e18448. ISSN 1932-6203

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Abstract

Feline urine spraying inside the home is a common problem behaviour that owners seek advice for from veterinarians. Individual trials relating to a variety of interventions produce variable results, and to date, no consensus on the value of different treatments has emerged. This study therefore aimed to meta-analyse, current data from appropriate published clinical trials that evaluate treatments for feline urine spraying. Inclusion and exclusion criteria for study selection were predefined and methodological quality was assessed by two independent reviewers. Ten studies in nine publications that either evaluated pharmacotherapy or pheromonatherapy (the use of a synthetic analogue of the F3 facial fraction in the cat) were suitable for analysis. There was a significant (P<0.001) association between the use of any intervention and the number of cats that ceased or reduced urine spraying by at least 90%. Analysis by intervention type indicated that fluoxetine, clomipramine and pheromonatherapy may each assist in managing urine spraying beyond a placebo based intervention. This is the first time meta-analytical techniques have been used and reported to evaluate the efficacy of interventions used in veterinary behavioural medicine, and it has established confidence in the value of both conventional treatments (pharmacotherapy) and a more recently developed treatment modality (pheromonatherapy) as an adjunct to the management of this problem. It is suggested that future research into treatment efficacy for this problem uses the benchmark standard of randomised, controlled trials lasting for at least 8 weeks, with the outcome criteria of cessation of feline urine spraying or reduction by at least 90%.

Item Type:	Journal article
Publication Title:	PLoS ONE
Creators:	Mills, D.S., Redgate, S.E. and Landsberg, G.M.
Date:	2011
Volume:	6
Number:	4
ISSN:	1932-6203
Identifiers:	Number Type 10.1371/journal.pone.0018448 DOI
Divisions:	Schools > School of Animal, Rural and Environmental Sciences
Record created by:	Jonathan Gallacher
Date Added:	16 Mar 2016 13:18
Last Modified:	09 Jun 2017 14:00
URI:	https://irep.ntu.ac.uk/id/eprint/27151

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