A magnetic resonance disruption (MaRDi) technique for the detection of surface immobilised magnetic nanoparticles

Parslow, ST ORCID: https://orcid.org/0000-0003-0861-6347, Hughes-Riley, TWB ORCID: https://orcid.org/0000-0001-8020-430X, Newton, MI ORCID: https://orcid.org/0000-0003-4231-1002 and Morris, RH ORCID: https://orcid.org/0000-0001-5511-3457, 2017. A magnetic resonance disruption (MaRDi) technique for the detection of surface immobilised magnetic nanoparticles. Analytical Methods. ISSN 1759-9660

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Abstract

There are numerous assays that result in a surface with bound magnetic nanoparticles (MNP) whose number is proportional to the concentration of the analyte of interest. The techniques used to explore such assays are typically complex and costly. Since the presence of such MNP disrupts the pulsed magnetic resonance signal that would normally be detected from a fluid covering the surface, we present a measurement technique to quantify such assays. In this work we identify and characterise a suitable fluid for such measurements, namely 10 cSt viscosity PDMS oil of thickness 250 μm. We demonstrate that the Teff2 relaxation time from the PDMS reduces as the proportion of the surface area covered with MNP increases. Most significant however, is a linear decrease in the signal amplitude from the PDMS as a function of MNP coverage. This is observed both for the integral over 4096 echoes and also in the first echo promising simplified console electronics for rapid measurements.

Item Type:	Journal article
Publication Title:	Analytical Methods
Creators:	Parslow, S.T., Hughes-Riley, T.W.B., Newton, M.I. and Morris, R.H.
Publisher:	Royal Society of Chemistry
Date:	21 February 2017
ISSN:	1759-9660
Identifiers:	Number Type 10.1039/C7AY00039A DOI
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	27 Feb 2017 12:11
Last Modified:	04 Apr 2019 11:15
URI:	https://irep.ntu.ac.uk/id/eprint/30279

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