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Papaccio, F, Paino, F, Regad, T 
ORCID: https://orcid.org/0000-0003-4028-6368, Papaccio, G, Desiderio, V and Tirino, V,
2017.
Concise review: cancer cells, cancer stem cells, and mesenchymal stem cells: influence in cancer development.
Stem Cells Translational Medicine.
ISSN 2157-6564
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Abstract
Tumors are composed of different types of cancer cells that contribute to tumor heterogeneity. Among these populations of cells, cancer stem cells (CSCs) play an important role in cancer initiation and progression. Like their stem cells counterpart, CSCs are also characterized by self-renewal and the capacity to differentiate. A particular population of CSCs is constituted by mesenchymal stem cells (MSCs) that differentiate into cells of mesodermal characteristics. Several studies have reported the potential pro-or anti-tumorigenic influence of MSCs on tumor initiation and progression. In fact, MSCs are recruited to the site of wound healing to repair damaged tissues, an event that is also associated with tumorigenesis. In other cases, resident or migrating MSCs can favor tumor angiogenesis and increase tumor aggressiveness. This interplay between MSCs and cancer cells is fundamental for cancerogenesis, progression, and metastasis. Therefore, an interesting topic is the relationship between cancer cells, CSCs, and MSCs, since contrasting reports about their respective influences have been reported. In this review, we discuss recent findings related to conflicting results on the influence of normal and CSCs in cancer development. The understanding of the role of MSCs in cancer is also important in cancer management.
| Item Type: | Journal article |
|---|---|
| Publication Title: | Stem Cells Translational Medicine |
| Creators: | Papaccio, F., Paino, F., Regad, T., Papaccio, G., Desiderio, V. and Tirino, V. |
| Publisher: | AlphaMed Press |
| Date: | 26 October 2017 |
| ISSN: | 2157-6564 |
| Identifiers: | Number Type 10.1002/sctm.17-0138 DOI |
| Divisions: | Schools > School of Science and Technology |
| Record created by: | Jonathan Gallacher |
| Date Added: | 27 Oct 2017 08:58 |
| Last Modified: | 27 Oct 2017 08:58 |
| URI: | https://irep.ntu.ac.uk/id/eprint/31900 |
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