Cancer chemotherapy in early life significantly alters the maturation of pain processing

Hathway, GJ, Murphy, E, Lloyd, J, Greenspon, C and Hulse, RP ORCID: https://orcid.org/0000-0002-5193-9822, 2017. Cancer chemotherapy in early life significantly alters the maturation of pain processing. Neuroscience. ISSN 0306-4522

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Abstract

Advances in pediatric cancer treatment have led to a ten year survival rate greater than 75%. Platinumbased chemotherapies (e.g. cisplatin) induce peripheral sensory neuropathy in adult and pediatric cancer patients. The period from birth through to adulthood represents a period of maturation within nociceptive systems. Here we investigated how cisplatin impacts upon postnatal maturation of nociceptive systems. Neonatal Wistar rats (Postnatal day (P) 7) were injected (i.p.) daily with either vehicle (PBS) or cisplatin (1mg/kg) for five consecutive days. Neither group developed mechanical or thermal hypersensitivity immediately during or after treatment. At P22 the cisplatin group developed mechanical (P < 0.05) and thermal (P < 0.0001) hypersensitivity versus vehicle group. Total DRG or dorsal horn neuronal number did not differ at P45, however there was an increase in intraepidermal nerve fiber density in cisplatin-treated animals at this age. The percentage of IB4+ve, CGRP+ve and NF200+ve DRG neurons was not different between groups at P45. There was an increase in TrkA +ve DRG neurons in the cisplatin group at P45, in addition to increased TrkA, NF200 and vGLUT2 immunoreactivity in the lumbar dorsal horn versus controls. These data highlight the impact pediatric cancer chemotherapy has upon the maturation of pain pathways and later life pain experience.

Item Type:	Journal article
Description:	In Special Issue entitled: SI: Pain Circuits.
Publication Title:	Neuroscience
Creators:	Hathway, G.J., Murphy, E., Lloyd, J., Greenspon, C. and Hulse, R.P.
Publisher:	Elsevier Ltd. on behalf of IBRO [International Brain Research Organization]
Date:	2 December 2017
ISSN:	0306-4522
Identifiers:	Number Type 10.1016/j.neuroscience.2017.11.032 DOI S0306452217308266 Publisher Item Identifier
Rights:	© 2017 Published by Elsevier Ltd. on behalf of IBRO [International Brain Research Organization]. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Divisions:	Schools > School of Science and Technology
Record created by:	Jill Tomkinson
Date Added:	04 Jan 2018 14:52
Last Modified:	20 Jul 2018 14:07
URI:	https://irep.ntu.ac.uk/id/eprint/32296

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