The importance of parameter choice in modelling dynamics of the eye lens

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Wang, K, Venetsanos, DT, Wang, J, Augousti, AT and Pierscionek, BK ORCID: https://orcid.org/0000-0002-8661-6353, 2017. The importance of parameter choice in modelling dynamics of the eye lens. Scientific Reports, 7 (1), p. 16688. ISSN 2045-2322

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Official URL: http://doi.org/10.1038/s41598-017-16854-9

Abstract

The lens provides refractive power to the eye and is capable of altering ocular focus in response to visual demand. This capacity diminishes with age. Current biomedical technologies, which seek to design an implant lens capable of replicating the function of the biological lens, are unable as yet to provide such an implant with the requisite optical quality or ability to change the focussing power of the eye. This is because the mechanism of altering focus, termed accommodation, is not fully understood and seemingly conflicting theories require experimental support which is difficult to obtain from the living eye. This investigation presents finite element models of the eye lens based on data from human lenses aged 16 and 35 years that consider the influence of various modelling parameters, including material properties, a wide range of angles of force application and capsular thickness. Results from axisymmetric models show that the anterior and posterior zonules may have a greater impact on shape change than the equatorial zonule and that choice of capsular thickness values can influence the results from modelled simulations.

Item Type:	Journal article
Publication Title:	Scientific Reports
Creators:	Wang, K., Venetsanos, D.T., Wang, J., Augousti, A.T. and Pierscionek, B.K.
Publisher:	Nature Publishing Group
Date:	2017
Volume:	7
Number:	1
ISSN:	2045-2322
Identifiers:	Number Type 10.1038/s41598-017-16854-9 DOI 16854 Publisher Item Identifier
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	24 Jan 2018 11:52
Last Modified:	24 Jan 2018 11:52
URI:	https://irep.ntu.ac.uk/id/eprint/32530