Nakagawa, S, Takeuchi, H, Taki, Y, Nouchi, R, Kotozaki, Y, Shinada, T, Maruyama, T, Sekiguchi, A, Iizuka, K, Yokoyama, R, Yamamoto, Y, Hanawa, S, Araki, T, Miyauchi, CM, Magistro, D ORCID: https://orcid.org/0000-0002-2554-3701, Sakaki, K, Jeong, H, Sasaki, Y and Kawashima, R, 2016. Basal ganglia correlates of fatigue in young adults. Scientific Reports, 6: 21386. ISSN 2045-2322
Preview |
Text
11010_Magistro.pdf - Published version Download (658kB) | Preview |
Abstract
Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease might be related to changes in the basal ganglia and prefrontal cortex and be implicated in fatigue with disease. We aimed to identify the white matter structures of fatigue in young subjects without disease using magnetic resonance imaging (MRI). Healthy young adults (n = 883; 489 males and 394 females) were recruited. As expected, the degrees of fatigue and motivation were associated with larger mean diffusivity (MD) in the right putamen, pallidus and caudate. Furthermore, the degree of physical activity was associated with a larger MD only in the right putamen. Accordingly, motivation was the best candidate for widespread basal ganglia, whereas physical activity might be the best candidate for the putamen. A plausible mechanism of fatigue may involve abnormal function of the motor system, as well as areas of the dopaminergic system in the basal ganglia that are associated with motivation and reward.
Item Type: | Journal article |
---|---|
Publication Title: | Scientific Reports |
Creators: | Nakagawa, S., Takeuchi, H., Taki, Y., Nouchi, R., Kotozaki, Y., Shinada, T., Maruyama, T., Sekiguchi, A., Iizuka, K., Yokoyama, R., Yamamoto, Y., Hanawa, S., Araki, T., Miyauchi, C.M., Magistro, D., Sakaki, K., Jeong, H., Sasaki, Y. and Kawashima, R. |
Publisher: | Nature Publishing Group |
Date: | 19 February 2016 |
Volume: | 6 |
ISSN: | 2045-2322 |
Identifiers: | Number Type 10.1038/srep21386 DOI BFsrep21386 Publisher Item Identifier |
Rights: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
Divisions: | Schools > School of Science and Technology |
Record created by: | Jonathan Gallacher |
Date Added: | 10 May 2018 10:27 |
Last Modified: | 10 May 2018 10:28 |
URI: | https://irep.ntu.ac.uk/id/eprint/33515 |
Actions (login required)
Edit View |
Statistics
Views
Views per month over past year
Downloads
Downloads per month over past year