Teaching new dogs old tricks: membrane biophysical properties in drug delivery and resistance

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Milosavljevic, N, Blanchard, A ORCID: https://orcid.org/0000-0001-6991-7210, Wahl, ML, Harguindey, S, Poet, M, Counillon, L and Rauch, C, 2011. Teaching new dogs old tricks: membrane biophysical properties in drug delivery and resistance. Recent Patents on Anti-Cancer Drug Discovery, 6 (3), pp. 334-346. ISSN 1574-8928

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Official URL: http://doi.org/10.2174/157489211796957829

Abstract

"How do drugs cross the plasma membrane?" this may seem like a trivial question. This question is often over-looked to focus primarily on the different complex macro-molecular aspects involved in drug delivery or drug resistance. However, recent studies have highlighted the theme that to be fully understood, more knowledge of the underlying biology of the most complex biological processes involved in the delivery and resistance to drugs is needed. After all, why would a drug interact with a transporter then subsequently be excluded from P-glycoprotein (P-gp) expressing drug resistant cells? What are the determinants of this transition in behavior? Full consideration of the physical biology of drug delivery has allowed a better understanding of the reasons why specific membrane proteins are upregulated or overexpressed in drug resistant cells. This, in turn, allows us to identify new targets for drug chemicals. Better yet, it increases the significance of recents patents and underlines their importance in multi drug resistance.

Item Type:	Journal article
Publication Title:	Recent Patents on Anti-Cancer Drug Discovery
Creators:	Milosavljevic, N., Blanchard, A., Wahl, M.L., Harguindey, S., Poet, M., Counillon, L. and Rauch, C.
Publisher:	Bentham Science
Date:	2011
Volume:	6
Number:	3
ISSN:	1574-8928
Identifiers:	Number Type 10.2174/157489211796957829 DOI LiveAll1 Other
Divisions:	Schools > School of Animal, Rural and Environmental Sciences
Record created by:	Linda Sullivan
Date Added:	16 Aug 2018 10:35
Last Modified:	07 Sep 2018 07:02
URI:	https://irep.ntu.ac.uk/id/eprint/34339