24-Week β-alanine ingestion does not affect muscle taurine or clinical blood parameters in healthy males

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Saunders, B, Franchi, M, De Oliveira, LF, Da Eira Silva, V, Da Silva, RP, De Salles Painelli, V, Costa, LAR, Sale, C ORCID: https://orcid.org/0000-0002-5816-4169, Harris, RC, Roschel, H, Artioli, GG ORCID: https://orcid.org/0000-0001-8463-2213 and Gualano, B, 2018. 24-Week β-alanine ingestion does not affect muscle taurine or clinical blood parameters in healthy males. European Journal of Nutrition, 59 (1), pp. 57-65. ISSN 1436-6207

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Official URL: http://doi.org/10.1007/s00394-018-1881-0

Abstract

Purpose: To investigate the effects of chronic beta-alanine (BA) supplementation on muscle taurine content, blood clinical markers and sensory side-effects.

Methods: Twenty-five healthy male participants (age 27±4 years, height 1.75±0.09 m, body mass 78.9±11.7 kg) were supplemented with 6.4 g day−1 of sustained-release BA (N=16; CarnoSyn™, NAI, USA) or placebo (PL; N=9; maltodextrin) for 24 weeks. Resting muscle biopsies of the m. vastus lateralis were taken at 0, 12 and 24 weeks and analysed for taurine content (BA, N=12; PL, N=6) using high-performance liquid chromatography. Resting venous blood samples were taken every 4 weeks and analysed for markers of renal, hepatic and muscle function (BA, N=15; PL, N=8; aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase; albumin; globulin; creatinine; estimated glomerular filtration rate and creatine kinase).

Results :There was a significant main effect of group (p=0.04) on muscle taurine, with overall lower values in PL, although there was no main effect of time or interaction effect (both p>0.05) and no differences between specific timepoints (week 0, BA: 33.67±8.18 mmol kg−1 dm, PL: 27.75±4.86 mmol kg−1 dm; week 12, BA: 35.93±8.79 mmol kg−1 dm, PL: 27.67±4.75 mmol kg−1 dm; week 24, BA: 35.42±6.16 mmol kg−1 dm, PL: 31.99±5.60 mmol kg−1 dm). There was no effect of treatment, time or any interaction effects on any blood marker (all p>0.05) and no self-reported side-effects in these participants throughout the study.

Conclusions: The current study showed that 24 weeks of BA supplementation at 6.4 g day−1 did not significantly affect muscle taurine content, clinical markers of renal, hepatic and muscle function, nor did it result in chronic sensory side-effects, in healthy individuals. Since athletes are likely to engage in chronic supplementation, these data provide important evidence to suggest that supplementation with BA at these doses for up to 24 weeks is safe for healthy individuals.

Item Type:	Journal article
Publication Title:	European Journal of Nutrition
Creators:	Saunders, B., Franchi, M., De Oliveira, L.F., Da Eira Silva, V., Da Silva, R.P., De Salles Painelli, V., Costa, L.A.R., Sale, C., Harris, R.C., Roschel, H., Artioli, G.G. and Gualano, B.
Publisher:	Springer Nature
Date:	14 December 2018
Volume:	59
Number:	1
ISSN:	1436-6207
Identifiers:	Number Type 10.1007/s00394-018-1881-0 DOI 1881 Publisher Item Identifier 688947 Other
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	03 Jan 2019 12:46
Last Modified:	31 May 2021 15:14
URI:	https://irep.ntu.ac.uk/id/eprint/35454