Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease

Chappell, S, Patel, T, Guetta-Baranes, T, Sang, F, Francis, PT, Morgan, K and Brookes, KJ ORCID: https://orcid.org/0000-0003-2427-2513, 2018. Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease. BMC Research Notes, 11 (1): 646. ISSN 1756-0500

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Abstract

Objectives: In order to determine how gene expression is altered in disease it is of fundamental importance that the global distribution of gene expression levels across the disease-free brain are understood and how differences between tissue types might inform tissue choice for investigation of altered expression in disease state. The aim of this pilot project was to use RNA-sequencing to investigate gene expression differences between five general areas of post-mortem human brain (frontal, temporal, occipital, parietal and cerebellum), and in particular changes in gene expression in the cerebellum compared to cortex regions for genes relevant to Alzheimer’s disease, as the cerebellum is largely preserved from disease pathology and could be an area of interest for neuroprotective pathways.

Results: General gene expression profiles were found to be similar between cortical regions of the brain, however the cerebellum presented a distinct expression profile. Focused exploration of gene expression for genes associated with Alzheimer’s disease suggest that those involved in the immunity pathway show little expression in the brain. Furthermore some Alzheimer’s disease associated genes display significantly different expression in the cerebellum compared with other brain regions, which might indicate potential neuroprotective measures.

Item Type:	Journal article
Publication Title:	BMC Research Notes
Creators:	Chappell, S., Patel, T., Guetta-Baranes, T., Sang, F., Francis, P.T., Morgan, K. and Brookes, K.J.
Publisher:	BioMed Central
Date:	2018
Volume:	11
Number:	1
ISSN:	1756-0500
Identifiers:	Number Type 10.1186/s13104-018-3732-8 DOI 3732 Publisher Item Identifier
Rights:	© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	13 May 2019 13:17
Last Modified:	13 May 2019 13:17
URI:	https://irep.ntu.ac.uk/id/eprint/36481

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