Faecal microRNAs as a non-invasive tool in the diagnosis of colonic adenomas and colorectal cancer: a meta-analysis

Yau, TO ORCID: https://orcid.org/0000-0002-3283-0370, Tang, C-M, Harriss, EK, Dickins, B ORCID: https://orcid.org/0000-0002-0866-6232 and Polytarchou, C ORCID: https://orcid.org/0000-0002-1948-7934, 2019. Faecal microRNAs as a non-invasive tool in the diagnosis of colonic adenomas and colorectal cancer: a meta-analysis. Scientific Reports, 9: 9491. ISSN 2045-2322

Preview

Text 14222_Dickins.pdf - Published version Download (2MB) | Preview

Abstract

MicroRNAs (miRNAs) are proposed as potential biomarkers for the diagnosis of numerous diseases. Here, we performed a meta-analysis to evaluate the utility of faecal miRNAs as a non-invasive tool in colorectal cancer (CRC) screening. A systematic literature search, according to predetermined criteria, in five databases identified 17 research articles including 6475, 783 and 5569 faecal-based miRNA tests in CRC, adenoma patients and healthy individuals, respectively. Sensitivity, specificity, positive/negative likelihood and diagnostic odds ratios, area under curve (AUC), summary receiver operator characteristic (sROC) curves, association of individual or combinations of miRNAs to cancer stage and location, subgroup, meta-regression and Deeks’ funnel plot asymmetry analyses were employed. Pooled miRNAs for CRC had an AUC of 0.811, with a sensitivity of 58.8% (95% confidence interval [CI]: 51.7–65.5%) and specificity of 84.8% (95% CI: 81.1–87.8%), whilst for colonic adenoma, it was 0.747, 57.3% (95% CI: 40.8–72.3%) and 76.1% (95% CI: 66.1–89.4%), respectively. The most reliable individual miRNA was miR-21, with an AUC of 0.843, sensitivity of 59.3% (95% CI: 26.3–85.6%) and specificity of 85.6% (95% CI: 72.2–93.2%). Paired stage analysis showed a better diagnostic accuracy in late stage CRC and sensitivity higher in distal than proximal CRC. In conclusion, faecal miR-21, miR-92a and their combination are promising non-invasive biomarkers for faecal-based CRC screening.

Item Type:	Journal article
Publication Title:	Scientific Reports
Creators:	Yau, T.O., Tang, C.-M., Harriss, E.K., Dickins, B. and Polytarchou, C.
Publisher:	Nature Publishing Group
Date:	1 July 2019
Volume:	9
ISSN:	2045-2322
Identifiers:	Number Type 10.1038/s41598-019-45570-9 DOI 45570 Publisher Item Identifier
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	04 Jul 2019 15:26
Last Modified:	04 Jul 2019 15:28
URI:	https://irep.ntu.ac.uk/id/eprint/37039

Actions (login required)

Edit View

Statistics

Views

Downloads