Search for novel diagnostic biomarkers of prostate inflammation-related disorders: role of transglutaminase isoforms as potential candidates

Savoca, MP ORCID: https://orcid.org/0000-0002-6465-341X, Inferrera, A, Verderio, EAM ORCID: https://orcid.org/0000-0001-9153-8997 and Caccamo, D, 2019. Search for novel diagnostic biomarkers of prostate inflammation-related disorders: role of transglutaminase isoforms as potential candidates. Mediators of Inflammation, 2019. ISSN 0962-9351

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Abstract

Investigations on prostate inflammation-related disorders, including acute and chronic prostatitis, chronic pelvic pain syndrome, benign prostate hyperplasia (BPH), and prostate cancer (PCa), are still ongoing to find new, accurate, and noninvasive biomarkers for a differential diagnosis of those pathological conditions sharing some common macroscopic features. Moreover, an ideal biomarker should be useful for risk assessment of prostate inflammation progression to more severe disorders, like BPH or PCa, as well as for monitoring of treatment response and prognosis establishment in carcinoma cases. Recent literature evidence highlighted that changes in the expression of transglutaminases, enzymes that catalyze transamidation reactions leading to posttranslational modifications of soluble proteins, occur in prostate inflammation-related disorders. This review focuses on the role specifically played by transglutaminases 4 (TG4) and 2 (TG2) and suggests that both isoenzymes hold a potential to be included in the list of candidates as novel diagnostic biomarkers for the above-cited prostate pathological conditions.

Item Type:	Journal article
Publication Title:	Mediators of Inflammation
Creators:	Savoca, M.P., Inferrera, A., Verderio, E.A.M. and Caccamo, D.
Publisher:	Hindawi
Date:	9 July 2019
Volume:	2019
ISSN:	0962-9351
Identifiers:	Number Type 10.1155/2019/7894017 DOI 7894017 Publisher Item Identifier
Rights:	Copyright © 2019 Maria Pia Savoca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	18 Jul 2019 11:55
Last Modified:	18 Jul 2019 11:55
URI:	https://irep.ntu.ac.uk/id/eprint/37113

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