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Smith, G, Smith, C 
ORCID: https://orcid.org/0000-0003-3285-0379, Kenny, JG, Chaudhuri, RR and Ritchie, MG,
2015.
Genome-wide DNA methylation patterns in wild samples of two morphotypes of threespine stickleback (Gasterosteus aculeatus).
Molecular Biology and Evolution, 32 (4), pp. 888-895.
ISSN 0737-4038
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Abstract
Epigenetic marks such as DNA methylation play important biological roles in gene expression regulation and cellular differentiation during development. To examine whether DNA methylation patterns are potentially associated with naturally occurring phenotypic differences, we examined genome-wide DNA methylation within Gasterosteus aculeatus, using reduced representation bisulfite sequencing. First, we identified highly methylated regions of the stickleback genome, finding such regions to be located predominantly within genes, and associated with genes functioning in metabolism and biosynthetic processes, cell adhesion, signaling pathways, and blood vessel development. Next, we identified putative differentially methylated regions (DMRs) of the genome between complete and low lateral plate morphs of G. aculeatus. We detected 77 DMRs that were mainly located in intergenic regions. Annotations of genes associated with these DMRs revealed potential functions in a number of known divergent adaptive phenotypes between G. aculeatus ecotypes, including cardiovascular development, growth, and neuromuscular development.
| Item Type: | Journal article |
|---|---|
| Publication Title: | Molecular Biology and Evolution |
| Creators: | Smith, G., Smith, C., Kenny, J.G., Chaudhuri, R.R. and Ritchie, M.G. |
| Publisher: | Oxford University Press on behalf of the Society for Molecular Biology and Evolution |
| Date: | April 2015 |
| Volume: | 32 |
| Number: | 4 |
| ISSN: | 0737-4038 |
| Identifiers: | Number Type 10.1093/molbev/msu344 DOI |
| Rights: | © The Author 2014. |
| Divisions: | Schools > School of Animal, Rural and Environmental Sciences |
| Record created by: | Jill Tomkinson |
| Date Added: | 19 Aug 2019 14:02 |
| Last Modified: | 19 Aug 2019 14:02 |
| URI: | https://irep.ntu.ac.uk/id/eprint/37358 |
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