Takeuchi, H, Taki, Y, Nouchi, R, Yokoyama, R, Kotozaki, Y, Nakagawa, S, Sekiguchi, A, Iizuka, K, Yamamoto, Y, Hanawa, S, Araki, T, Miyauchi, C, Sakaki, K, Nozawa, T, Ikeda, S, Yokota, S, Daniele, M ORCID: https://orcid.org/0000-0002-2554-3701, Sassa, Y and Kawashima, R, 2019. Association of iron levels in hair with brain structures and functions in young adults. Journal of Trace Elements in Medicine and Biology. ISSN 0946-672X
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Abstract
Background: Iron plays a critical role in normal brain functions and development, but it has also been known to have adverse neurological effects.
Methods: Here, we investigated the associations of iron levels in hair with regional gray matter volume (rGMV), regional cerebral blood flow (rCBF), fractional anisotropy (FA), mean diffusivity (MD), and cognitive differences in a study cohort of 590 healthy young adults.
Results: Our findings showed that high iron levels were associated with lower rGMV in areas including the hippocampus, lower rCBF in the anterior and posterior parts of the brain, greater FA in areas including the part of the splenium of the corpus callosum, lower MD in the overlapping area including the splenium of the corpus callosum, as well as greater MD in the left hippocampus and areas including the frontal lobe.
Conclusion: These results are compatible with the notion that iron plays diverse roles in neural mechanisms in healthy young adults.
Item Type: | Journal article |
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Alternative Title: | Iron, brain structures, and perfusion [short title] |
Publication Title: | Journal of Trace Elements in Medicine and Biology |
Creators: | Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Yamamoto, Y., Hanawa, S., Araki, T., Miyauchi, C., Sakaki, K., Nozawa, T., Ikeda, S., Yokota, S., Daniele, M., Sassa, Y. and Kawashima, R. |
Publisher: | Elsevier BV |
Date: | 13 November 2019 |
ISSN: | 0946-672X |
Identifiers: | Number Type 10.1016/j.jtemb.2019.126436 DOI 1239396 Other S0946672X19302834 Publisher Item Identifier |
Divisions: | Schools > School of Science and Technology |
Record created by: | Linda Sullivan |
Date Added: | 21 Nov 2019 15:34 |
Last Modified: | 21 Nov 2019 15:35 |
URI: | https://irep.ntu.ac.uk/id/eprint/38431 |
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