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El hadad, AA, García-Galván, FR, Mezour, MA, Hickman, GJ 
ORCID: https://orcid.org/0000-0002-4632-9229, Soliman, IE, Jiménez-Morales, A, Barranco, V, Galván, JC and Perry, CC ORCID: https://orcid.org/0000-0003-1517-468X,
2020.
Organic-inorganic hybrid coatings containing phosphorus precursors prepared by sol–gel on Ti6Al4V alloy: electrochemical and in-vitro biocompatibility evaluation.
Progress in Organic Coatings, 148: 105834.
ISSN 0300-9440
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Abstract
The durability and long-term success of metallic implants are enhanced through the molecular scale design of biocompatible and corrosion resistant surface coatings. To pursue this hypothesis, we have developed a new class of organic-inorganic (O-I) hybrid nanocomposite coatings based on tetramethylorthosilicate (TMOS) and γ-methacryloxypropyltrimethoxysilane (MAPTMS) as organofunctional alkoxysilanes precursors and dimethyltrimethylsilylphosphite (DMTMSP) as a phosphorus precursor. Addition of DMTMSP to TMOS-MAPTMS hybrids increased the extent of intermolecular condensation and cross-linking observed. Both normal human osteoblast in-vitro biocompatibility and corrosion resistance were enhanced in coatings containing DMTMSP. Though increasing phosphorous content correlated with biocompatibility, a compromise in the amount of phosphorus incorporated would be required if corrosion resistance was the most desirable parameter for optimization, at least for single coat systems. Evaluation of the electrochemical behaviour and the in-vitro biocompatibility show that films prepared using these materials by dip coating onto Ti6Al4V alloys offer a promising alternative to simpler coatings and wholly metallic prostheses.
| Item Type: | Journal article |
|---|---|
| Publication Title: | Progress in Organic Coatings |
| Creators: | El hadad, A.A., García-Galván, F.R., Mezour, M.A., Hickman, G.J., Soliman, I.E., Jiménez-Morales, A., Barranco, V., Galván, J.C. and Perry, C.C. |
| Publisher: | Elsevier |
| Date: | November 2020 |
| Volume: | 148 |
| ISSN: | 0300-9440 |
| Identifiers: | Number Type 10.1016/j.porgcoat.2020.105834 DOI 1332774 Other S030094401931611X Publisher Item Identifier |
| Divisions: | Schools > School of Science and Technology |
| Record created by: | Jonathan Gallacher |
| Date Added: | 23 Jun 2020 14:03 |
| Last Modified: | 18 Jun 2021 03:00 |
| URI: | https://irep.ntu.ac.uk/id/eprint/40088 |
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