Skeletal muscle insulin signaling and whole-body glucose metabolism following acute sleep restriction in healthy males

Sweeney, EL ORCID: https://orcid.org/0000-0002-6946-2989, Jeromson, S, Hamilton, DL, Brooks, NE and Walshe, IH, 2017. Skeletal muscle insulin signaling and whole-body glucose metabolism following acute sleep restriction in healthy males. Physiological Reports, 5 (23), e13498. ISSN 2051-817X

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Abstract

Sleep restriction is associated with impaired glucose metabolism and insulin resistance, however, the underlying mechanisms leading to this impairment are unknown. This study aimed to assess whether the decrease in insulin sensitivity observed after sleep restriction is accompanied by changes in skeletal muscle PKB activity. Ten healthy young males participated in this randomized crossover study which included two conditions separated by a 3‐week washout period. Participants underwent two nights of habitual sleep (CON) and two nights of sleep which was restricted to 50% of habitual sleep duration (SR) in the home environment. Whole‐body glucose tolerance and insulin sensitivity were assessed by an oral glucose tolerance test after the second night of each condition. Skeletal muscle tissue samples were obtained from the vastus lateralis to determine PKB activity. Findings displayed no effect of trial on plasma glucose concentrations (P = 0.222). Plasma insulin area under the curve was higher after sleep restriction compared to the control (P = 0.013). Matsuda index was 18.6% lower in the sleep restriction (P = 0.010). Fold change in PKB activity from baseline tended to be lower in the sleep restriction condition at 30 min (P = 0.098) and 120 min (P = 0.087). In conclusion, we demonstrated decreased whole‐body insulin sensitivity in healthy young males following two nights of sleep restriction. Skeletal muscle insulin signaling findings are inconclusive and require further study to examine any potential changes.

Item Type:	Journal article
Publication Title:	Physiological Reports
Creators:	Sweeney, E.L., Jeromson, S., Hamilton, D.L., Brooks, N.E. and Walshe, I.H.
Publisher:	Wiley
Date:	December 2017
Volume:	5
Number:	23
ISSN:	2051-817X
Identifiers:	Number Type 10.14814/phy2.13498 DOI 1371622 Other
Rights:	© 2017 the authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Available under Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0/).
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	02 Oct 2020 15:29
Last Modified:	31 May 2021 15:15
URI:	https://irep.ntu.ac.uk/id/eprint/41133

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