Helfer, G and Dumbell, R ORCID: https://orcid.org/0000-0002-8805-3777, 2020. Endocrine drivers of photoperiod response. Current Opinion in Endocrine and Metabolic Research, 11, pp. 49-54. ISSN 2451-9650
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Abstract
Life in a seasonally variable environment has evolved to interpret the time of year through day length (photoperiod) which is translated into a neurochemical signal. In mammals, the pars tuberalis is a key site where seasonal time signal (melatonin) interfaces and relays photoperiodic information to the hypothalamus via thyrotropin. Recent work has elucidated a potential circannual clock in ‘calendar cells’ of the pars tuberalis. In the hypothalamus, tanycytes are an integral part of the hypothalamic network. Previous studies show the importance of local synthesis of thyroid hormone and retinoic acid in tanycytes. Recently, novel downstream neuroendocrine signals, for example, VGF, FGF21 and chemerin, were identified to govern seasonally appropriate phenotype. In addition, the hypothalamic pituitary growth axis has been implicated in seasonally body weight and torpor regulation. Here, we will focus on the endocrine drivers of photoperiod response and highlight novel downstream effects on body weight and growth focussing on recent findings from seasonal rodent studies.
Item Type: | Journal article |
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Publication Title: | Current Opinion in Endocrine and Metabolic Research |
Creators: | Helfer, G. and Dumbell, R. |
Publisher: | Elsevier |
Date: | April 2020 |
Volume: | 11 |
ISSN: | 2451-9650 |
Identifiers: | Number Type 10.1016/j.coemr.2020.01.001 DOI S2451965020300016 Publisher Item Identifier 1371457 Other |
Divisions: | Schools > School of Science and Technology |
Record created by: | Linda Sullivan |
Date Added: | 07 Dec 2020 12:14 |
Last Modified: | 31 May 2021 15:08 |
URI: | https://irep.ntu.ac.uk/id/eprint/41791 |
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