Endocrine drivers of photoperiod response

Helfer, G. and Dumbell, R. ORCID: 0000-0002-8805-3777, 2020. Endocrine drivers of photoperiod response. Current Opinion in Endocrine and Metabolic Research, 11, pp. 49-54. ISSN 2451-9650

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Life in a seasonally variable environment has evolved to interpret the time of year through day length (photoperiod) which is translated into a neurochemical signal. In mammals, the pars tuberalis is a key site where seasonal time signal (melatonin) interfaces and relays photoperiodic information to the hypothalamus via thyrotropin. Recent work has elucidated a potential circannual clock in ‘calendar cells’ of the pars tuberalis. In the hypothalamus, tanycytes are an integral part of the hypothalamic network. Previous studies show the importance of local synthesis of thyroid hormone and retinoic acid in tanycytes. Recently, novel downstream neuroendocrine signals, for example, VGF, FGF21 and chemerin, were identified to govern seasonally appropriate phenotype. In addition, the hypothalamic pituitary growth axis has been implicated in seasonally body weight and torpor regulation. Here, we will focus on the endocrine drivers of photoperiod response and highlight novel downstream effects on body weight and growth focussing on recent findings from seasonal rodent studies.

Item Type: Journal article
Publication Title: Current Opinion in Endocrine and Metabolic Research
Creators: Helfer, G. and Dumbell, R.
Publisher: Elsevier
Date: April 2020
Volume: 11
ISSN: 2451-9650
S2451965020300016Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 07 Dec 2020 12:14
Last Modified: 31 May 2021 15:08
URI: https://irep.ntu.ac.uk/id/eprint/41791

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