Circadian clocks, stress, and immunity

Dumbell, R. ORCID: 0000-0002-8805-3777, Matveeva, O. and Oster, H., 2016. Circadian clocks, stress, and immunity. Frontiers in Endocrinology, 7: 37. ISSN 1664-2392

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In mammals, molecular circadian clocks are present in most cells of the body, and this circadian network plays an important role in synchronizing physiological processes and behaviors to the appropriate time of day. The hypothalamic–pituitary–adrenal endocrine axis regulates the response to acute and chronic stress, acting through its final effectors – glucocorticoids – released from the adrenal cortex. Glucocorticoid secretion, characterized by its circadian rhythm, has an important role in synchronizing peripheral clocks and rhythms downstream of the master circadian pacemaker in the suprachiasmatic nucleus. Finally, glucocorticoids are powerfully anti-inflammatory, and recent work has implicated the circadian clock in various aspects and cells of the immune system, suggesting a tight interplay of stress and circadian systems in the regulation of immunity. This mini-review summarizes our current understanding of the role of the circadian clock network in both the HPA axis and the immune system, and discusses their interactions.

Item Type: Journal article
Publication Title: Frontiers in Endocrinology
Creators: Dumbell, R., Matveeva, O. and Oster, H.
Publisher: Frontiers Media SA
Date: 2 May 2016
Volume: 7
ISSN: 1664-2392
Rights: Copyright © 2016 Dumbell, Matveeva and Oster. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Divisions: Schools > School of Science and Technology
Record created by: Jeremy Silvester
Date Added: 09 Dec 2020 11:51
Last Modified: 31 May 2021 15:09

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