High glucose load and endotoxemia among overweight and obese Arab women with and without diabetes: an observational study

Al-Disi, D, Ansari, MGA, Sabico, S, Wani, K, Hussain, DS, Elshafie, MM, McTernan, P ORCID: https://orcid.org/0000-0001-9023-0261 and Al-Daghri, NM, 2020. High glucose load and endotoxemia among overweight and obese Arab women with and without diabetes: an observational study. Medicine, 99 (46): e23211. ISSN 0025-7974

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Abstract

Dietary intake influences gut microbiota activity. Nevertheless, there is a lack of evidence available that illustrates the acute effects of high glucose meal on metabolic endotoxemia. The present study assessed the acute impact of high glucose meal on endotoxemia and other clinical parameters in Saudi females with varying degrees of glycemia.

The subjects were 64 consenting pre-menopausal women, grouped into 3: control [n = 14 lean, non-T2DM, BMI = 22.2 ± 2.2 kg/m2]; overweight [n = 16, non-T2DM, BMI = 28.5 ± 1.5 kg/m2] and T2DM [n = 34, BMI = 35.2 ± 7.7 kg/m2]. After an overnight fast, all subjects were given a standardized high-glucose (75 g) meal. Anthropometrics were taken and blood samples were withdrawn at baseline and postprandial (0, 2 and 4-hours), serum glucose, endotoxin and lipid profile were quantified.

At baseline, total cholesterol, LDL-cholesterol, triglycerides and serum glucose levels were significantly higher (P values <.01) whereas significantly lower HDL-cholesterol levels (P < .01) were observed in T2DM subjects compared to other groups. Baseline endotoxin levels were highest in the overweight group (3.2 ± 1.1 mmol/L) as compared to control (2.0 ± 0.5 mmol/L) and T2DM (2.7 ± 1.2 mmol/L) (P = .046). HDL-cholesterol, LDL-cholesterol and triglycerides, significantly decreased in the T2DM group after 2 hours (P values <.05), whereas unremarkable changes observed in other groups. Lastly, endotoxin levels significantly increased only in the overweight group (3.2 ± 1.1 vs 4.2 ± 1.4 mmol/L; P < .05), 4 hours postprandial.

High glucose meal elevates endotoxemia only among overweight subjects and impairs dysbiosis.

Item Type:	Journal article
Alternative Title:	Dietary intake influences gut microbiota endotoxin levels
Publication Title:	Medicine
Creators:	Al-Disi, D., Ansari, M.G.A., Sabico, S., Wani, K., Hussain, D.S., Elshafie, M.M., McTernan, P. and Al-Daghri, N.M.
Publisher:	Lippincott, Williams and Wilkins
Date:	13 November 2020
Volume:	99
Number:	46
ISSN:	0025-7974
Identifiers:	Number Type 10.1097/MD.0000000000023211 DOI 1380733 Other
Rights:	Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	12 Jan 2021 12:09
Last Modified:	31 May 2021 15:08
URI:	https://irep.ntu.ac.uk/id/eprint/42014

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