Mechanisms that shape microbial pangenomes

Domingo-Sananes, MR ORCID: https://orcid.org/0000-0002-3339-8671 and McInerney, JO, 2021. Mechanisms that shape microbial pangenomes. Trends in Microbiology. ISSN 0966-842X

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Abstract

Analyses of multiple whole-genome sequences from the same species have revealed that differences in gene content can be substantial, particularly in prokaryotes. Such variation has led to the recognition of pangenomes, the complete set of genes present in a species – consisting of core genes present in all individuals, and accessory genes whose presence is variable. Questions now arise about how pangenomes originate and evolve. We describe how gene content variation can arise as a result of the combination of several processes including random drift, selection, gain-loss balance, and the influence of ecological and epistatic interactions. We believe that identifying
the contributions of these processes to pangenomes will need novel theoretical approaches and empirical data.

Item Type:	Journal article
Publication Title:	Trends in Microbiology
Creators:	Domingo-Sananes, M.R. and McInerney, J.O.
Publisher:	Elsevier
Date:	7 January 2021
ISSN:	0966-842X
Identifiers:	Number Type 10.1016/j.tim.2020.12.004 DOI 1399624 Other
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	15 Jan 2021 16:13
Last Modified:	07 Jan 2022 03:00
URI:	https://irep.ntu.ac.uk/id/eprint/42051

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