Reliability of transcranial magnetic stimulation measurements of maximum activation of the knee extensors in young adult males

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Malcolm, R ORCID: https://orcid.org/0000-0003-3494-3835, Cooper, S ORCID: https://orcid.org/0000-0001-5219-5020, Folland, J, Hannah, R, Tyler, C and Sunderland, C ORCID: https://orcid.org/0000-0001-7484-1345, 2021. Reliability of transcranial magnetic stimulation measurements of maximum activation of the knee extensors in young adult males. Human Movement Science, 78: 102828. ISSN 0167-9457

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Official URL: https://doi.org/10.1016/j.humov.2021.102828

Abstract

Purpose: Transcranial magnetic stimulation (TMS) provides an indication of changes occurring in the corticospinal pathway. This study aimed to determine the between-day (trials 1 week apart) and within-day (trials 1 h apart) reliability of TMS and peripheral nerve stimulation.

Methods: 22 male participants (age 23 ± 4 years; height 1.80 ± 0.07 m; body mass 75.1 ± 11.7 kg; body mass index 23.1 ± 2.5 kg.m 2) completed 2 familiarisation sessions and 3 experimental trials (trial 2 and 3 split by 1 h). The interpolated twitch technique was used to determine TMS-assessed voluntary activations (VA-TMS) superimposed on submaximal and maximal leg extension performed on a custom-built dynamometer. Reliability was assessed using equivalence tests, systematic error, 95% limits of agreement, intraclass correlation coefficient (ICC) and coefficient of variation (CV).

Results: VA-TMS was equivalent between-day (94.1 ± 4.4% versus 93.7 ± 4.9%, P < 0.01) and within-day (93.7 ± 4.9% versus 93.7 ± 4.8%, P < 0.01). Systematic error (95% limits of agreement) for VA-TMS was 0.5% (5.1%, 4.2%) for between-day and 0.0% 2 (5.3%, 5.4%) for within-day. ICC and CV values demonstrated high reliability between-day (ICC = 0.93, CV = 2.5%) and within-day (ICC = 0.92, CV = 2.9%).

Conclusion: Results indicate that TMS can reliably estimate the output of the motor cortex to the knee extensors, both between-day and within-day. The findings have been used to estimate sample sizes for this technique for future research.

Item Type:	Journal article
Publication Title:	Human Movement Science
Creators:	Malcolm, R., Cooper, S., Folland, J., Hannah, R., Tyler, C. and Sunderland, C.
Publisher:	Elsevier
Date:	August 2021
Volume:	78
ISSN:	0167-9457
Identifiers:	Number Type 10.1016/j.humov.2021.102828 DOI S0167945721000762 Publisher Item Identifier 1447868 Other
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	28 Jun 2021 08:09
Last Modified:	03 Dec 2022 03:00
URI:	https://irep.ntu.ac.uk/id/eprint/43252