Rhodium(III)-catalyzed enantioselective benzamidation of cyclopropenes

Antonchick, AP ORCID: https://orcid.org/0000-0003-0435-9443, Waldmann, H, Shaaban, S, Li, H and Merten, C, 2021. Rhodium(III)-catalyzed enantioselective benzamidation of cyclopropenes. Synthesis, 53 (13), pp. 2192-2200. ISSN 0039-7881

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Abstract

Cyclopropylamines are characteristic structural motifs found in a variety of natural products and pharmaceuticals and therefore engaging targets for the development of new methods for their synthesis. Herein the synthesis of enantioenriched cyclopropylamines through catalytic enantioselective C–H functionalization using a chiral RhJasCp complex is reported. The reaction proceeds under mild conditions with high enantiocontrol. This reaction enables access to cyclopropylamines with three contiguous stereocenters originating from the corresponding cyclopropenes.

Item Type:	Journal article
Alternative Title:	Rh(III)-catalyzed enantioselective benzamidation of cyclopropenes
Publication Title:	Synthesis
Creators:	Antonchick, A.P., Waldmann, H., Shaaban, S., Li, H. and Merten, C.
Publisher:	Georg Thieme Verlag KG
Date:	July 2021
Volume:	53
Number:	13
ISSN:	0039-7881
Identifiers:	Number Type 10.1055/s-0040-1706026 DOI 1447717 Other
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	01 Jul 2021 08:10
Last Modified:	18 Feb 2022 03:00
URI:	https://irep.ntu.ac.uk/id/eprint/43282

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