Editorial: radioimmunotherapy—translational opportunities and challenges

Gaipl, US, Multhoff, G, Pockley, AG ORCID: https://orcid.org/0000-0001-9593-6431 and Rödel, F, 2020. Editorial: radioimmunotherapy—translational opportunities and challenges. Frontiers in Oncology, 10: 190. ISSN 2234-943X

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Abstract

It has become evident that radiotherapy has both, immune suppressive, and immune activating properties (1). This is why this important component of cancer treatment should be combined with immune therapies to shift the balance toward immune activation against tumor cells. During the last decade a manifold of pre-clinical work was put into investigation of combination of radiotherapy either with additional immune stimulants such as cytokines or vaccines or in combination with antibodies that target immune suppressive molecules such as immune checkpoint inhibitors. Luckily, some of these approaches are currently tested in clinical trials, high lightening the huge translational opportunities by examination of modes of action of radiotherapy in combination with immunotherapy; named in this special issue radioimmunotherapy. However, one has always to keep in mind that many challenges do still exist such as what is the best sequence and timing of joint applications, what are the best immunotherapy approaches, how to overcome tumor resistances, what about healthy tissue cytotoxicity, or which biomarkers or matrices of biomarkers are most beneficial for patients stratification, just to mention the most burning ones. The articles in this special issue grab many of these challenges.

Item Type:	Journal article
Publication Title:	Frontiers in Oncology
Creators:	Gaipl, U.S., Multhoff, G., Pockley, A.G. and Rödel, F.
Publisher:	Frontiers Media SA
Date:	21 February 2020
Volume:	10
ISSN:	2234-943X
Identifiers:	Number Type 10.3389/fonc.2020.00190 DOI 1341063 Other
Rights:	© 2020 Gaipl, Multhoff, Pockley and Rödel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Divisions:	Schools > School of Science and Technology
Record created by:	Laura Ward
Date Added:	16 Jul 2021 10:20
Last Modified:	16 Jul 2021 10:20
URI:	https://irep.ntu.ac.uk/id/eprint/43506

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