Improvement in visual perception after high-frequency transcranial random noise stimulation (hf-tRNS) in those with migraine: an equivalent noise approach.

O'Hare, L ORCID: https://orcid.org/0000-0003-0331-3646, Goodwin, P ORCID: https://orcid.org/0000-0002-1396-2626, Sharp, A, Contillo, A and Pavan, A, 2021. Improvement in visual perception after high-frequency transcranial random noise stimulation (hf-tRNS) in those with migraine: an equivalent noise approach. Neuropsychologia, 161: 107990. ISSN 0028-3932

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Abstract

Migraine is a common neurological disorder with strong links to vision. Interictal migraine is thought to be characterised by internal noise in the brain, possibly due to increased variability in neural firing, which can be estimated using equivalent noise tasks. High-frequency transcranial random noise stimulation (hf-tRNS) can be used to modulate levels of internal noise in the brain, and so presents a possible therapy to redress noise levels in the migraine brain. This is a case-control study using a 2-alternative forced choice (2AFC) design. hf-tRNS and Sham control stimulation were used alongside a global motion direction discrimination task and visually based equivalent noise tasks. The migraine group demonstrated increased baseline internal noise levels compared to the control group. Internal noise levels, and sampling, were reduced using hf-tRNS but not Sham stimulation. However, there were no differences in terms of coherence thresholds, slopes, and lapse rate for global motion discrimination between the two groups. This is the first demonstration of the possibility of decreasing internal noise levels in migraine using hf-tRNS. Future work could explore the possibility of neurostimulation as a therapy for migraine.

Item Type:	Journal article
Publication Title:	Neuropsychologia
Creators:	O'Hare, L., Goodwin, P., Sharp, A., Contillo, A. and Pavan, A.
Publisher:	Elsevier
Date:	15 October 2021
Volume:	161
ISSN:	0028-3932
Identifiers:	Number Type 10.1016/j.neuropsychologia.2021.107990 DOI 1460133 Other
Divisions:	Schools > School of Social Sciences
Record created by:	Laura Ward
Date Added:	17 Aug 2021 13:27
Last Modified:	14 Aug 2022 03:00
URI:	https://irep.ntu.ac.uk/id/eprint/44026

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