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Polychronidou, V, Krupp, A, Strohmann, C and Antonchick, AP 
ORCID: https://orcid.org/0000-0003-0435-9443,
2021.
Cascade aza-Wittig/6π-electrocyclization in the synthesis of 1,6-dihydropyridines.
Organic Letters, 23 (15), pp. 6024-6029.
ISSN 1523-7060
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Abstract
A metal-free protocol for the synthesis of substituted 1,6-dihydropyridines with quaternary stereogenic centers via a cascade aza-Wittig/6π-electrocyclization process has been developed. The high functional group compatibility and broad scope of this method were demonstrated by using a wide range of easily available vinyliminophosphoranes and ketones, with yields up to 97%. A modification of the obtained products allowed for an increase in complexity and chemical diversity. Finally, attempts for asymmetric synthesis of 1,6-dihydropyridines are demonstrated.
| Item Type: | Journal article |
|---|---|
| Publication Title: | Organic Letters |
| Creators: | Polychronidou, V., Krupp, A., Strohmann, C. and Antonchick, A.P. |
| Publisher: | American Chemical Society (ACS) |
| Date: | 6 August 2021 |
| Volume: | 23 |
| Number: | 15 |
| ISSN: | 1523-7060 |
| Identifiers: | Number Type 10.1021/acs.orglett.1c02099 DOI 1470104 Other |
| Rights: | © 2021 The Authors. Published by American Chemical Society. |
| Divisions: | Schools > School of Science and Technology |
| Record created by: | Laura Ward |
| Date Added: | 10 Sep 2021 15:53 |
| Last Modified: | 10 Sep 2021 15:53 |
| URI: | https://irep.ntu.ac.uk/id/eprint/44154 |
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