Polychronidou, V., Krupp, A., Strohmann, C. and Antonchick, A.P. ORCID: 0000-0003-0435-9443, 2021. Cascade aza-Wittig/6π-electrocyclization in the synthesis of 1,6-dihydropyridines. Organic Letters, 23 (15), pp. 6024-6029. ISSN 1523-7060
|
Text
1470104_Antonchick.pdf - Published version Download (1MB) | Preview |
Abstract
A metal-free protocol for the synthesis of substituted 1,6-dihydropyridines with quaternary stereogenic centers via a cascade aza-Wittig/6π-electrocyclization process has been developed. The high functional group compatibility and broad scope of this method were demonstrated by using a wide range of easily available vinyliminophosphoranes and ketones, with yields up to 97%. A modification of the obtained products allowed for an increase in complexity and chemical diversity. Finally, attempts for asymmetric synthesis of 1,6-dihydropyridines are demonstrated.
Item Type: | Journal article | ||||||
---|---|---|---|---|---|---|---|
Publication Title: | Organic Letters | ||||||
Creators: | Polychronidou, V., Krupp, A., Strohmann, C. and Antonchick, A.P. | ||||||
Publisher: | American Chemical Society (ACS) | ||||||
Date: | 6 August 2021 | ||||||
Volume: | 23 | ||||||
Number: | 15 | ||||||
ISSN: | 1523-7060 | ||||||
Identifiers: |
|
||||||
Rights: | © 2021 The Authors. Published by American Chemical Society. | ||||||
Divisions: | Schools > School of Science and Technology | ||||||
Record created by: | Laura Ward | ||||||
Date Added: | 10 Sep 2021 15:53 | ||||||
Last Modified: | 10 Sep 2021 15:53 | ||||||
URI: | https://irep.ntu.ac.uk/id/eprint/44154 |
Actions (login required)
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year