Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex

Takeuchi, H, Kimura, R, Tomita, H, Taki, Y, Kikuchi, Y, Ono, C, Yu, Z, Matsudaira, I, Nouchi, R, Yokoyama, R, Kotozaki, Y, Nakagawa, S, Hanawa, S, Iizuka, K, Sekiguchi, A, Araki, T, Miyauchi, CM, Ikeda, S, Sakaki, K, dos S. Kawata, KH, Nozawa, T, Yokota, S, Magistro, D ORCID: https://orcid.org/0000-0002-2554-3701, Imanishi, T and Kawashima, R, 2021. Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex. Human Brain Mapping. ISSN 1065-9471

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Abstract

It has been hypothesized that a higher genetic risk of bipolar disorder (BD) is associated with greater creativity. Given the clinical importance of bipolar disorder and the importance of creativity to human society and cultural development, it is essential to reveal their associations and the neural basis of the genetic risk of bipolar disorder to gain insight into its etiology. However, despite the previous demonstration of the associations of polygenic risk score (PRS) of BD and creative jobs, the associations of BD-PRS and creativity measured by the divergent thinking (CMDT) and regional gray matter volume (rGMV) as well as regional white matter volume (rWMV) have not been investigated. Using psychological analyses and whole-brain voxel-by-voxel analyses, we examined these potential associations in 1558 young, typically developing adult students. After adjusting for confounding variables and multiple comparisons, a greater BD-PRS was associated with a greater total CMDT fluency score, and a significant relationship was found in fluency subscores. A greater BD-PRS was also associated with lower total mood disturbance. Neuroimaging analyses revealed that the BD-PRS was associated with greater rGMV in the right inferior frontal gyrus, which is a consistently affected area in BD, as well as a greater rWMV in the left middle frontal gyrus, which has been suggested to play a central role in the increased creativity associated with the risk of BD with creativity. These findings suggest a relationship between the genetic risk of BD and CMDT and prefrontal cortical structures among young educated individuals.

Item Type:	Journal article
Publication Title:	Human Brain Mapping
Creators:	Takeuchi, H., Kimura, R., Tomita, H., Taki, Y., Kikuchi, Y., Ono, C., Yu, Z., Matsudaira, I., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Hanawa, S., Iizuka, K., Sekiguchi, A., Araki, T., Miyauchi, C.M., Ikeda, S., Sakaki, K., dos S. Kawata, K.H., Nozawa, T., Yokota, S., Magistro, D., Imanishi, T. and Kawashima, R.
Publisher:	Wiley
Date:	29 September 2021
ISSN:	1065-9471
Identifiers:	Number Type 10.1002/hbm.25667 DOI 1475344 Other
Rights:	© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	01 Oct 2021 15:23
Last Modified:	01 Oct 2021 15:23
URI:	https://irep.ntu.ac.uk/id/eprint/44309

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