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Wang, Z, Zeng, M, Wang, Z, Qin, F, Wang, Y, Chen, J, Christian, M 
ORCID: https://orcid.org/0000-0002-1616-4179 and He, Z,
2021.
Food phenolics stimulate adipocyte browning via regulating gut microecology.
Critical Reviews in Food Science and Nutrition.
ISSN 1040-8398
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Abstract
Fat browning has piqued the interest of researchers as a potential target for treating obesity and related metabolic disorders. Recruitment of brown adipocytes leads to enhanced energy dissipation and reduced adiposity, thus facilitating the maintenance of metabolic homeostasis. Evidence is increasing to support the crucial roles of polyphenols and gut microecology in turning fat “brown”. However, it is not clear whether the intestinal microecology is involved in polyphenol-mediated regulation of adipose browning, so this concept is worthy of exploration. In this review, we summarize the current knowledge, mostly from studies with murine models, supporting the concept that the effects of food phenolics on brown fat activation and white fat browning can be attributed to their regulatory actions on gut microecology, including microbial community profile, gut metabolites, and gut-derived hormones. Furthermore, the potential underlying pathways involved are also discussed. Basically, understanding gut microecology paves the way to determine the underlying roles and mechanisms of food phenolics in adipose browning.
| Item Type: | Journal article |
|---|---|
| Publication Title: | Critical Reviews in Food Science and Nutrition |
| Creators: | Wang, Z., Zeng, M., Wang, Z., Qin, F., Wang, Y., Chen, J., Christian, M. and He, Z. |
| Publisher: | Informa UK Limited |
| Date: | 5 November 2021 |
| ISSN: | 1040-8398 |
| Identifiers: | Number Type 10.1080/10408398.2021.1997905 DOI 1496034 Other |
| Rights: | This is an Accepted Manuscript of an article published by Taylor & Francis in Critical Reviews in Food Science and Nutrition on 5th November 2021, available online: http://www.tandfonline.com/10.1080/10408398.2021.1997905 |
| Divisions: | Schools > School of Science and Technology |
| Record created by: | Laura Ward |
| Date Added: | 18 Nov 2021 15:49 |
| Last Modified: | 05 Nov 2022 03:00 |
| URI: | https://irep.ntu.ac.uk/id/eprint/44878 |
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