Cardiopulmonary exercise performance and factors associated with aerobic capacity in neuromuscular diseases

Ramdharry, GM, Wallace, A, Hennis, P ORCID: https://orcid.org/0000-0002-8216-998X, Dewar, E, Dudziec, M, Jones, K, Pietrusz, A, Reilly, MM and Hanna, MG, 2021. Cardiopulmonary exercise performance and factors associated with aerobic capacity in neuromuscular diseases. Muscle and Nerve, 64 (6), pp. 683-690. ISSN 0148-639X

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Abstract

Introduction/Aims: Aerobic deconditioning, due to lower levels of physical activity, could impact independence for people with neuromuscular conditions. We report the maximal cardiopulmonary response in a cohort of people with Charcot Marie Tooth disease type 1A (CMT 1A) and inclusion body myositis (IBM). We also explored potential predictors of aerobic capacity with measures of physical impairment and functional performance.

Methods: Participants underwent maximal cardiopulmonary exercise testing (CPET) using a semi-recumbent cycle ergometer. Data were analyzed to determine the peak O2 consumption (VO2 peak), anaerobic threshold (AT), maximum heart rate (MHR), ventilatory equivalent for CO2 slope (VE/VCO2), and respiratory exchange ratio (RER). Impairment, functional and patient reported measures were also recorded. Predicted CPET variables were calculated based on published normative data for age, gender, and weight.

Results: Twenty-two people with CMT and 17 people with IBM were recruited. Both groups showed significantly lower VO2 peak, MHR, AT, and VE/VCO2. The CMT group overall performed better than the IBM group, with significantly higher VO2 peak, MHR, and AT, but lower VE/VCO2. Linear regression analysis demonstrated that VO2 peak was related to body fat percentage and 6-min walk distance for both groups, and steps per day for the IBM group.

Discussion: Lower than predicted CPET variables were observed that were not explained by cardiopulmonary limitations or reduced effort, implicating peripheral factors in limiting the cycling task. Regression analysis implied prediction of VO2 peak by body fat percentage and 6-min walk distance. Six-minute walk distance could be a potential proxy measure of cardiopulmonary fitness.

Item Type:	Journal article
Publication Title:	Muscle and Nerve
Creators:	Ramdharry, G.M., Wallace, A., Hennis, P., Dewar, E., Dudziec, M., Jones, K., Pietrusz, A., Reilly, M.M. and Hanna, M.G.
Publisher:	Wiley
Date:	December 2021
Volume:	64
Number:	6
ISSN:	0148-639X
Identifiers:	Number Type 10.1002/mus.27423 DOI 1476218 Other
Rights:	© 2021 The Authors. Muscle & Nerve published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Divisions:	Schools > School of Science and Technology
Record created by:	Laura Ward
Date Added:	22 Nov 2021 10:51
Last Modified:	22 Nov 2021 10:51
URI:	https://irep.ntu.ac.uk/id/eprint/44908

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