Hypoxia-induced carbonic anhydrase mediated dorsal horn sensory neuron activation and induction of neuropathic pain

Da Vitoria Lobo, ME, Weir, N, Hardowar, L, Al Ojaimi, Y, Madden, R, Gibson, A, Bestall, SM, Hirashima, M, Schaffer, CB, Donaldson, LF, Bates, DO and Hulse, RP ORCID: https://orcid.org/0000-0002-5193-9822, 2022. Hypoxia-induced carbonic anhydrase mediated dorsal horn sensory neuron activation and induction of neuropathic pain. PAIN. ISSN 0304-3959

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Abstract

Neuropathic pain such as that seen in diabetes mellitus, results in part from central sensitisation in the dorsal horn. However, the mechanisms responsible for such sensitisation remain unclear. There is evidence that disturbances in the integrity of the spinal vascular network can be causative factors in the development of neuropathic pain. Here we show that reduced blood flow and vascularity of the dorsal horn leads to the onset of neuropathic pain. Using rodent models (type 1 diabetes and an inducible endothelial specific vascular endothelial growth factor receptor 2 knockout mouse) that result in degeneration of the endothelium in the dorsal horn we show that spinal cord vasculopathy results in nociceptive behavioural hypersensitivity. This also results in increased hypoxia in dorsal horn neurons, depicted by increased expression of hypoxia markers hypoxia inducible factor 1

Item Type:	Journal article
Publication Title:	PAIN
Creators:	Da Vitoria Lobo, M.E., Weir, N., Hardowar, L., Al Ojaimi, Y., Madden, R., Gibson, A., Bestall, S.M., Hirashima, M., Schaffer, C.B., Donaldson, L.F., Bates, D.O. and Hulse, R.P.
Publisher:	Lippincott, Williams & Wilkins
Date:	29 March 2022
ISSN:	0304-3959
Identifiers:	Number Type 10.1097/j.pain.0000000000002627 DOI 1520998 Other
Rights:	Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	06 Apr 2022 10:23
Last Modified:	29 Mar 2023 03:00
URI:	https://irep.ntu.ac.uk/id/eprint/46066

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