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Hui, C and Antonchick, AP 
ORCID: https://orcid.org/0000-0003-0435-9443,
2022.
Concise synthesis of piperarborenine B.
Bioorganic and Medicinal Chemistry, 67: 116817.
ISSN 0968-0896
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Abstract
A concise synthesis of piperarborenine B is reported. Organocatalytic electrophilic amination of pyrrolidines, stereospecific oxidative ring contraction and an original diastereoselective Krapcho dealkoxycarbonylation/transmethylation contribute to a novel synthetic strategy to the preparation of a non-symmetrical cyclobutane core. Being transition-metal-free, directing-group-free and protecting-group-free, a five-step synthesis of piperarborenine B was accomplished.
| Item Type: | Journal article |
|---|---|
| Publication Title: | Bioorganic and Medicinal Chemistry |
| Creators: | Hui, C. and Antonchick, A.P. |
| Publisher: | Elsevier BV |
| Date: | August 2022 |
| Volume: | 67 |
| ISSN: | 0968-0896 |
| Identifiers: | Number Type 10.1016/j.bmc.2022.116817 DOI 1547770 Other |
| Divisions: | Schools > School of Science and Technology |
| Record created by: | Laura Ward |
| Date Added: | 23 May 2022 09:45 |
| Last Modified: | 20 May 2023 03:00 |
| URI: | https://irep.ntu.ac.uk/id/eprint/46347 |
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