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Hui, C. and Antonchick, A.P. 
ORCID: 0000-0003-0435-9443,
2022.
Concise synthesis of piperarborenine B.
Bioorganic and Medicinal Chemistry, 67: 116817.
ISSN 0968-0896
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Abstract
A concise synthesis of piperarborenine B is reported. Organocatalytic electrophilic amination of pyrrolidines, stereospecific oxidative ring contraction and an original diastereoselective Krapcho dealkoxycarbonylation/transmethylation contribute to a novel synthetic strategy to the preparation of a non-symmetrical cyclobutane core. Being transition-metal-free, directing-group-free and protecting-group-free, a five-step synthesis of piperarborenine B was accomplished.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Bioorganic and Medicinal Chemistry | ||||||
| Creators: | Hui, C. and Antonchick, A.P. | ||||||
| Publisher: | Elsevier BV | ||||||
| Date: | August 2022 | ||||||
| Volume: | 67 | ||||||
| ISSN: | 0968-0896 | ||||||
| Identifiers: |
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| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Laura Ward | ||||||
| Date Added: | 23 May 2022 09:45 | ||||||
| Last Modified: | 20 May 2023 03:00 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/46347 |
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