Penney, N, Yeung, D, Garcia-Perez, I, Posma, J, Kopytek, A, Garratt, B, Ashrafian, H, Frost, G, Marchesi, J, Purkayastha, S, Hoyles, L ORCID: https://orcid.org/0000-0002-6418-342X, Darzi, A and Holmes, E, 2022. Multi-omic phenotyping reveals host-microbe responses to bariatric surgery, glycaemic control and obesity. Communications Medicine, 2: 127. ISSN 2730-664X
Full text not available from this repository.Abstract
Background: Resolution of type 2 diabetes (T2D) is common following bariatric surgery, particularly Roux-en-Y gastric bypass. However, the underlying mechanisms have not been fully elucidated.
Methods: To address this we compare the integrated serum, urine and faecal metabolic profiles of participants with obesity +/- T2D (n=80, T2D=42) with participants who underwent Roux-en-Y gastric bypass or sleeve gastrectomy (pre and 3-months post-surgery; n=27), taking diet into account. We co-model these data with shotgun metagenomic profiles of the gut microbiota to provide a comprehensive atlas of host-gut microbe responses to bariatric surgery, weight-loss and glycaemic control at the systems level.
Results: Here we show that bariatric surgery reverses several disrupted pathways characteristic of T2D. The differential metabolite set representative of bariatric surgery overlaps with both diabetes (19.3% commonality) and body mass index (18.6% commonality). However, the percentage overlap between diabetes and body mass index is minimal (4.0% commonality), consistent with weight independent mechanisms of T2D resolution. The gut microbiota is more strongly correlated to body mass index than T2D, although we identify some pathways such as amino acid metabolism that correlate with changes to the gut microbiota and which influence glycaemic control.
Conclusion: We identify multi-omic signatures associated with responses to surgery, body mass index, and glycaemic control. Improved understanding of gut microbiota - host co-metabolism may lead to novel therapies for weight-loss or diabetes. However, further experiments are required to provide mechanistic insight into the role of the gut microbiota in host metabolism and establish proof of causality.
Item Type: | Journal article |
---|---|
Publication Title: | Communications Medicine |
Creators: | Penney, N., Yeung, D., Garcia-Perez, I., Posma, J., Kopytek, A., Garratt, B., Ashrafian, H., Frost, G., Marchesi, J., Purkayastha, S., Hoyles, L., Darzi, A. and Holmes, E. |
Publisher: | Nature Publishing Group |
Date: | 7 October 2022 |
Volume: | 2 |
ISSN: | 2730-664X |
Identifiers: | Number Type 10.1038/s43856-022-00185-6 DOI 1597236 Other |
Divisions: | Schools > School of Science and Technology |
Record created by: | Jonathan Gallacher |
Date Added: | 20 Sep 2022 15:10 |
Last Modified: | 10 Oct 2022 09:17 |
URI: | https://irep.ntu.ac.uk/id/eprint/47056 |
Actions (login required)
Edit View |
Statistics
Views
Views per month over past year
Downloads
Downloads per month over past year