3D-printed microfluidic droplet generation systems for drug delivery applications

Noroozi, R, Mashhadi Kashtiban, M, Taghvaei, H, Zolfagharian, A and Bodaghi, M ORCID logoORCID: https://orcid.org/0000-0002-0707-944X, 2022. 3D-printed microfluidic droplet generation systems for drug delivery applications. Materials Today: Proceedings. ISSN 2214-7853

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Abstract

Drug delivery systems are advanced methods that aim to deliver a targeted drug to a specific location or release it at a controlled rate. Many methods have been proposed for drug delivery systems, among which microfluidic systems present unique advantages. In contrast to bulk methods, in this work, by considering the unique capacity of microfluidic-based drug delivery systems, including controllability of fabricated chip geometry and flow rate of multiphase fluid, highly stable particles with higher encapsulation efficiency can be generated. Employing additive manufacturing in biomedical applications has enabled researchers to propose novel and accurate microfluidic systems. In this paper, by employing stereolithography (SLA) and fused deposition modeling (FDM) 3D printing, a microfluidic-based drug delivery system for generating polycaprolactone (PCL) droplets loaded with dexamethasone drug is fabricated. Scanning electron microscope (SEM) images and microscopic images show the effectiveness of this method in generating such droplets.

Item Type: Journal article
Publication Title: Materials Today: Proceedings
Creators: Noroozi, R., Mashhadi Kashtiban, M., Taghvaei, H., Zolfagharian, A. and Bodaghi, M.
Publisher: Elsevier BV
Date: 29 September 2022
ISSN: 2214-7853
Identifiers:
Number
Type
10.1016/j.matpr.2022.09.363
DOI
1606622
Other
Rights: © 2022 Elsevier Ltd. All rights reserved. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Divisions: Schools > School of Science and Technology
Record created by: Jeremy Silvester
Date Added: 06 Oct 2022 08:33
Last Modified: 06 Oct 2022 08:33
URI: https://irep.ntu.ac.uk/id/eprint/47218

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