Ring contraction in synthesis of functionalized carbocycles

Hui, C, Craggs, L and Antonchick, AP ORCID: https://orcid.org/0000-0003-0435-9443, 2022. Ring contraction in synthesis of functionalized carbocycles. Chemical Society Reviews. ISSN 0306-0012

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Abstract

Carbocycles are a key and widely present structural motif in organic compounds. The construction of structurally intriguing carbocycles, such as highly-strained fused rings, spirocycles or highly-functionalized carbocycles with congested stereocenters, remains challenging in organic chemistry. Cyclopropanes, cyclobutanes and cyclopentanes within such carbocycles can be synthesized through ring contraction. These ring contractions involve re-arrangement of and/or small molecule extrusion from a parental ring, which is either a carbocycle or a heterocycle of larger size. This review provides an overview of synthetic methods for ring contractions to form cyclopropanes, cyclobutanes and cyclopentanes en route to structurally intriguing carbocycles.

Item Type:	Journal article
Publication Title:	Chemical Society Reviews
Creators:	Hui, C., Craggs, L. and Antonchick, A.P.
Publisher:	Royal Society of Chemistry (RSC)
Date:	29 September 2022
ISSN:	0306-0012
Identifiers:	Number Type 10.1039/d1cs01080h DOI 1607696 Other
Rights:	© The Royal Society of Chemistry 2022. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Divisions:	Schools > School of Science and Technology
Record created by:	Laura Ward
Date Added:	10 Oct 2022 15:50
Last Modified:	10 Oct 2022 15:50
URI:	https://irep.ntu.ac.uk/id/eprint/47234

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