Hui, C., Craggs, L. and Antonchick, A.P. ORCID: 0000-0003-0435-9443, 2022. Ring contraction in synthesis of functionalized carbocycles. Chemical Society Reviews. ISSN 0306-0012
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Abstract
Carbocycles are a key and widely present structural motif in organic compounds. The construction of structurally intriguing carbocycles, such as highly-strained fused rings, spirocycles or highly-functionalized carbocycles with congested stereocenters, remains challenging in organic chemistry. Cyclopropanes, cyclobutanes and cyclopentanes within such carbocycles can be synthesized through ring contraction. These ring contractions involve re-arrangement of and/or small molecule extrusion from a parental ring, which is either a carbocycle or a heterocycle of larger size. This review provides an overview of synthetic methods for ring contractions to form cyclopropanes, cyclobutanes and cyclopentanes en route to structurally intriguing carbocycles.
Item Type: | Journal article | ||||||
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Publication Title: | Chemical Society Reviews | ||||||
Creators: | Hui, C., Craggs, L. and Antonchick, A.P. | ||||||
Publisher: | Royal Society of Chemistry (RSC) | ||||||
Date: | 29 September 2022 | ||||||
ISSN: | 0306-0012 | ||||||
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Rights: | © The Royal Society of Chemistry 2022. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. | ||||||
Divisions: | Schools > School of Science and Technology | ||||||
Record created by: | Laura Ward | ||||||
Date Added: | 10 Oct 2022 15:50 | ||||||
Last Modified: | 10 Oct 2022 15:50 | ||||||
URI: | https://irep.ntu.ac.uk/id/eprint/47234 |
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