Mesoporous one-component gold microshells as 3D SERS substrates

Vikulina, AS, Stetsyura, IY, Onses, MS, Yılmaz, E, Skirtach, AG and Volodkin, D ORCID: https://orcid.org/0000-0001-7474-5329, 2021. Mesoporous one-component gold microshells as 3D SERS substrates. Biosensors, 11 (10): 380.

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Abstract

Surface-enhanced Raman scattering (SERS) is a powerful analytical tool for label-free analysis that has found a broad spectrum of applications in material, chemical, and biomedical sciences. In recent years, a great interest has been witnessed in the rational design of SERS substrates to amplify Raman signals and optionally allow for the selective detection of analytes, which is especially essential and challenging for biomedical applications. In this study, hard templating of noble metals is proposed as a novel approach for the design of one-component tailor-made SERS platforms. Porous Au microparticles were fabricated via dual ex situ adsorption of Au nanoparticles and in situ reduction of HAuCl4 on mesoporous sacrificial microcrystals of vaterite CaCO3. Elimination of the microcrystals at mild conditions resulted in the formation of stable mesoporous one-component Au microshells. SERS performance of the microshells at very low 0.4 µW laser power was probed using rhodamine B and bovine serum albumin showing enhancement factors of 2 × 108 and 8 × 108, respectively. The proposed strategy opens broad avenues for the design and scalable fabrication of one-component porous metal particles that can serve as superior SERS platforms possessing both excellent plasmonic properties and the possibility of selective inclusion of analyte molecules and/or SERS nanotags for highly specific SERS analysis.

Item Type:	Journal article
Publication Title:	Biosensors
Creators:	Vikulina, A.S., Stetsyura, I.Y., Onses, M.S., Yılmaz, E., Skirtach, A.G. and Volodkin, D.
Publisher:	MDPI AG
Date:	2021
Volume:	11
Number:	10
Identifiers:	Number Type 10.3390/bios11100380 DOI 1618216 Other
Rights:	© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	22 Nov 2022 09:40
Last Modified:	22 Nov 2022 09:40
URI:	https://irep.ntu.ac.uk/id/eprint/47461

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