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Rabbani, N, Adaikalakoteswari, A 
ORCID: https://orcid.org/0000-0003-2974-3388, Larkin, JR, Panagiotopoulos, S, MacIsaac, RJ, Yue, DK, Fulcher, GR, Roberts, MA, Thomas, M, Ekinci, E and Thornalley, PJ,
2022.
Analysis of serum advanced glycation endproducts reveals methylglyoxal-derived advanced glycation MG-H1 free adduct is a risk marker in non-diabetic and diabetic chronic kidney disease.
International Journal of Molecular Sciences, 24 (1): 152.
ISSN 1661-6596
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Abstract
Accumulation of advanced glycation endproducts (AGEs) is linked decline in renal function, particularly in patients with diabetes. Major forms of AGEs in serum are protein-bound AGEs and AGE free adducts. In this study, we assessed levels of AGEs in subjects with and without diabetes, with normal renal function and stages 2 to 4 chronic kidney disease (CKD), to identify which AGE has the greatest progressive change with decline in renal function and change in diabetes. We performed a cross-sectional study of patients with stages 2 – 4 CKD, with and without diabetes, and healthy controls (n = 135). Nine protein-bound and free adduct AGEs were quantified in serum. Most protein-bound AGEs increased moderately through stages 2 – 4 CKD whereas AGE free adducts increased markedly. Methylglyoxal-derived hydroimidazolone MG-H1 free adduct was the AGE most responsive to CKD status, increasing by 8-fold and 30-fold in stage 4 CKD in patients without and with diabetes, respectively. MG-H1 Glomerular filtration flux was increased 5-fold in diabetes, likely reflecting increased methylglyoxal glycation status. We conclude that serum MG-H1 free adduct concentration was strongly related to stage and increased in diabetes status. Serum MG-H1 free adduct is a candidate AGE risk marker of non-diabetic and diabetic CKD.
| Item Type: | Journal article |
|---|---|
| Publication Title: | International Journal of Molecular Sciences |
| Creators: | Rabbani, N., Adaikalakoteswari, A., Larkin, J.R., Panagiotopoulos, S., MacIsaac, R.J., Yue, D.K., Fulcher, G.R., Roberts, M.A., Thomas, M., Ekinci, E. and Thornalley, P.J. |
| Publisher: | MDPI |
| Date: | 21 December 2022 |
| Volume: | 24 |
| Number: | 1 |
| ISSN: | 1661-6596 |
| Identifiers: | Number Type 10.3390/ijms24010152 DOI 1626498 Other |
| Divisions: | Schools > School of Science and Technology |
| Record created by: | Laura Ward |
| Date Added: | 12 Dec 2022 10:19 |
| Last Modified: | 14 Dec 2023 09:30 |
| URI: | https://irep.ntu.ac.uk/id/eprint/47621 |
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