Vandelannoote, K, Phanzu, DM, Kibadi, K, Eddyani, M, Meehan, CJ ORCID: https://orcid.org/0000-0003-0724-8343, Jordaens, K, Leirs, H, Portaels, F, Stinear, TP, Harris, SR and de Jong, BC, 2019. Mycobacterium ulcerans population genomics to inform on the spread of Buruli ulcer across Central Africa. mSphere, 4 (1): e00472-18. ISSN 2379-5042
Full text not available from this repository.Abstract
Buruli ulcer is a neglected tropical disease of skin and subcutaneous tissue caused by infection with the pathogen Mycobacterium ulcerans. Many critical issues for disease control, such as understanding the mode of transmission and identifying source reservoirs of M. ulcerans, are still largely unknown. Here, we used genomics to reconstruct in detail the evolutionary trajectory and dynamics of M. ulcerans populations at a central African scale and at smaller geographical village scales. Whole-genome sequencing (WGS) data were analyzed from 179 M. ulcerans strains isolated from all Buruli ulcer foci in the Democratic Republic of the Congo, The Republic of Congo, and Angola that have ever yielded positive M. ulcerans cultures. We used both temporal associations and the study of the mycobacterial demographic history to estimate the contribution of humans as a reservoir in Buruli ulcer transmission. Our phylogeographic analysis revealed one almost exclusively predominant sublineage of M. ulcerans that arose in Central Africa and proliferated in its different regions of endemicity during the Age of Discovery. We observed how the best sampled endemic hot spot, the Songololo territory, became an area of endemicity while the region was being colonized by Belgium (1880s). We furthermore identified temporal parallels between the observed past population fluxes of M. ulcerans from the Songololo territory and the timing of health policy changes toward control of the Buruli ulcer epidemic in that region. These findings suggest that an intervention based on detecting and treating human cases in an area of endemicity might be sufficient to break disease transmission chains, irrespective of other reservoirs of the bacterium.
Item Type: | Journal article |
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Publication Title: | mSphere |
Creators: | Vandelannoote, K., Phanzu, D.M., Kibadi, K., Eddyani, M., Meehan, C.J., Jordaens, K., Leirs, H., Portaels, F., Stinear, T.P., Harris, S.R. and de Jong, B.C. |
Publisher: | American Society for Microbiology |
Date: | 6 February 2019 |
Volume: | 4 |
Number: | 1 |
ISSN: | 2379-5042 |
Identifiers: | Number Type 10.1128/msphere.00472-18 DOI 1627037 Other |
Rights: | This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
Divisions: | Schools > School of Science and Technology |
Record created by: | Jonathan Gallacher |
Date Added: | 12 Dec 2022 15:15 |
Last Modified: | 12 Dec 2022 15:15 |
URI: | https://irep.ntu.ac.uk/id/eprint/47632 |
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