Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control

Baker, M, Williams, AD, Hooton, SPT, Helliwell, R, King, E, Dodsworth, T, María Baena-Nogueras, R, Warry, A, Ortori, CA, Todman, H, Gray-Hammerton, CJ, Pritchard, ACW, Iles, E, Cook, R, Emes, RD ORCID: https://orcid.org/0000-0001-6855-5481, Jones, MA, Kypraios, T, West, H, Barrett, DA, Ramsden, SJ, Gomes, RL, Hudson, C, Millard, AD, Raman, S, Morris, C, Dodd, CER, Kreft, J-U, Hobman, JL and Stekel, DJ, 2022. Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control. Environment International, 169: 107516. ISSN 0160-4120

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Abstract

Waste from dairy production is one of the largest sources of contamination from antimicrobial resistant bacteria (ARB) and genes (ARGs) in many parts of the world. However, studies to date do not provide necessary evidence to inform antimicrobial resistance (AMR) countermeasures. We undertook a detailed, interdisciplinary, longitudinal analysis of dairy slurry waste. The slurry contained a population of ARB and ARGs, with resistances to current, historical and never-used on-farm antibiotics; resistances were associated with Gram-negative and Gram-positive bacteria and mobile elements (ISEcp1, Tn916, Tn21-family transposons). Modelling and experimental work suggested that these populations are in dynamic equilibrium, with microbial death balanced by fresh input. Consequently, storing slurry without further waste input for at least 60 days was predicted to reduce ARB spread onto land, with > 99 % reduction in cephalosporin resistant Escherichia coli. The model also indicated that for farms with low antibiotic use, further reductions are unlikely to reduce AMR further. We conclude that the slurry tank is a critical point for measurement and control of AMR, and that actions to limit the spread of AMR from dairy waste should combine responsible antibiotic use, including low total quantity, avoidance of human critical antibiotics, and choosing antibiotics with shorter half-lives, coupled with appropriate slurry storage.

Item Type:	Journal article
Publication Title:	Environment International
Creators:	Baker, M., Williams, A.D., Hooton, S.P.T., Helliwell, R., King, E., Dodsworth, T., María Baena-Nogueras, R., Warry, A., Ortori, C.A., Todman, H., Gray-Hammerton, C.J., Pritchard, A.C.W., Iles, E., Cook, R., Emes, R.D., Jones, M.A., Kypraios, T., West, H., Barrett, D.A., Ramsden, S.J., Gomes, R.L., Hudson, C., Millard, A.D., Raman, S., Morris, C., Dodd, C.E.R., Kreft, J.-U., Hobman, J.L. and Stekel, D.J.
Publisher:	Elsevier
Date:	November 2022
Volume:	169
ISSN:	0160-4120
Identifiers:	Number Type 10.1016/j.envint.2022.107516 DOI S0160412022004433 Publisher Item Identifier 1655427 Other
Rights:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Record created by:	Jonathan Gallacher
Date Added:	07 Feb 2023 13:46
Last Modified:	07 Feb 2023 13:46
URI:	https://irep.ntu.ac.uk/id/eprint/48185

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