Gene expression profile induced by two different variants of street rabies virus in mice

Appolinário, CM, Daly, JM, Emes, RD ORCID: https://orcid.org/0000-0001-6855-5481, Marchi, FA, Ribeiro, BLD and Megid, J, 2022. Gene expression profile induced by two different variants of street rabies virus in mice. Viruses, 14 (4): 692. ISSN 1999-4915

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Abstract

Pathogenicity and pathology of rabies virus (RABV) varies according to the variant, but the mechanisms are not completely known. In this study, gene expression profile in brains of mice experimentally infected with RABV isolated from a human case of dog rabies (V2) or vampire bat-acquired rabies (V3) were analyzed. In total, 138 array probes associated with 120 genes were expressed differentially between mice inoculated with V2 and sham-inoculated control mice at day 10 post-inoculation. A single probe corresponding to an unannotated gene was identified in V3 versus control mice. Gene ontology (GO) analysis revealed that all of the genes upregulated in mice inoculated with V2 RABV were involved in the biological process of immune defense against pathogens. Although both variants are considered pathogenic, inoculation by the same conditions generated different gene expression results, which is likely due to differences in pathogenesis between the dog and bat RABV variants. This study demonstrated the global gene expression in experimental infection due to V3 wild-type RABV, from the vampire bat Desmodus rotundus, an important source of infection for humans, domestic animals and wildlife in Latin America.

Item Type:	Journal article
Publication Title:	Viruses
Creators:	Appolinário, C.M., Daly, J.M., Emes, R.D., Marchi, F.A., Ribeiro, B.L.D. and Megid, J.
Publisher:	MDPI
Date:	27 March 2022
Volume:	14
Number:	4
ISSN:	1999-4915
Identifiers:	Number Type 10.3390/v14040692 DOI 1655656 Other
Rights:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Divisions:	Professional Services > The Directorate
Record created by:	Jonathan Gallacher
Date Added:	08 Feb 2023 11:54
Last Modified:	08 Feb 2023 11:54
URI:	https://irep.ntu.ac.uk/id/eprint/48196

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